Silver nanoparticles: A new view on mechanistic aspects on antimicrobial activity.

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Abstract

Silver nanoparticles are well known potent antimicrobial agents. Although significant progresses have been achieved on the elucidation of antimicrobial mechanism of silver nanoparticles, the exact mechanism of action is still not completely known. This overview incorporates a retrospective of previous reviews published and recent original contributions on the progress of research on antimicrobial mechanisms of silver nanoparticles. The main topics discussed include release of silver nanoparticles and silver ions, cell membrane damage, DNA interaction, free radical generation, bacterial resistance and the relationship of resistance to silver ions versus resistance to silver nanoparticles. The focus of the overview is to summarize the current knowledge in the field of antibacterial activity of silver nanoparticles. The possibility that pathogenic microbes may develop resistance to silver nanoparticles is also discussed.

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Author and article information

Journal

Journal ID (iso-abbrev): Nanomedicine

Title: Nanomedicine : nanotechnology, biology, and medicine

ISSN (Electronic): 1549-9642

ISSN (Print): 1549-9634

Publication date (Electronic): Apr 2016

Volume: 12

Issue: 3

Affiliations

[1 ] Institute of Chemistry, Biological Chemistry Laboratory, University of Campinas, Campinas, SP, Brazil; NanoBioss, Institute of Chemistry, University of Campinas, Campinas, SP, Brazil; Brazilian National Nanotechnology Laboratory (LNNano-CNPEM), Campinas, SP, Brazil. Electronic address: duran@iqm.unicamp.br.

[2 ] NanoBioss, Institute of Chemistry, University of Campinas, Campinas, SP, Brazil; Institute of Biology, Urogenital, Carcinogenesis and Immunotherapy Laboratory, University of Campinas, SP, Brazil.

[3 ] Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, UNICAMP, Campinas, SP, Brazil.

[4 ] Exact and Earth Sciences Department, Federal University of São Paulo, Diadema, SP, Brazil. Electronic address: amedea.seabra@gmail.com.

[5 ] Department of Microbiology, Biology Sciences Center, Londrina State University (UEL), Londrina, Brazil.

Article

Publisher Item ID: S1549-9634(15)00600-0

DOI: 10.1016/j.nano.2015.11.016

PubMed ID: 26724539

SO-VID: 879e9422-dcdc-4364-af2b-2525cd94cd02

History

Keywords: Antibacterial,Bacterial resistance,Silver nanoparticles,Toxicity

Data availability:

Keywords: Antibacterial, Bacterial resistance, Silver nanoparticles, Toxicity

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