Understanding the molecular basis of cardiomyopathy

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Abstract

Inherited cardiomyopathies are a major cause of mortality and morbidity worldwide and can be caused by mutations in a wide range of proteins located in different cellular compartments. The present review is based on Dr. Ju Chen’s 2021 Robert M. Berne Distinguished Lectureship of the American Physiological Society Cardiovascular Section, in which he provided an overview of the current knowledge on the cardiomyopathy-associated proteins that have been studied in his laboratory. The review provides a general summary of the proteins in different compartments of cardiomyocytes associated with cardiomyopathies, with specific focus on the proteins that have been studied in Dr. Chen’s laboratory.

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Author and article information

Contributors

Marie-Louise Bang: (View ORCID Profile)

Julius Bogomolovas: (View ORCID Profile)

Ju Chen: (View ORCID Profile)

Journal

Title: American Journal of Physiology-Heart and Circulatory Physiology

Abbreviated Title: American Journal of Physiology-Heart and Circulatory Physiology

Publisher: American Physiological Society

ISSN (Print): 0363-6135

ISSN (Electronic): 1522-1539

Publication date Created: February 01 2022

Publication date (Print): February 01 2022

Volume: 322

Issue: 2

Pages: H181-H233

Affiliations

[1 ]Institute of Genetic and Biomedical Research (IRGB), National Research Council (CNR), Milan Unit, Milan, Italy

[2 ]IRCCS Humanitas Research Hospital, Rozzano (Milan), Italy

[3 ]Division of Cardiovascular Medicine, Department of Medicine Cardiology, University of California, San Diego, La Jolla, California

Article

DOI: 10.1152/ajpheart.00562.2021

PubMed ID: 34797172

SO-VID: 86dd8add-4a11-4d22-8016-ea7a4434c65e

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