For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
8
views
182
references
 Top references
cited by
9
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      212
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Chemical and Biological Research on Herbal Medicines Rich in Xanthones

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Xanthones, as some of the most active components and widely distributed in various herb medicines, have drawn more and more attention in recent years. So far, 168 species of herbal plants belong to 58 genera, 24 families have been reported to contain xanthones. Among them, Calophyllum, Cratoxylum, Cudrania, Garcinia, Gentiana, Hypericum and Swertia genera are plant resources with great development prospect. This paper summarizes the plant resources, bioactivity and the structure-activity relationships (SARs) of xanthones from references published over the last few decades, which may be useful for new drug research and development on xanthones.

          Related collections

          Most cited references182

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          Biological Activities and Bioavailability of Mangosteen Xanthones: A Critical Review of the Current Evidence

          Fabiola Gutierrez-Orozco, Mark L. Failla (2013)
          Mangosteen (Garcinia mangostana L.) is a tropical tree native to Southeast Asia that produces a fruit whose pericarp contains a family of tricyclic isoprenylated polyphenols referred to as xanthones. Numerous in vitro studies have shown that these xanthones possess anti-oxidant, anti-proliferative, pro-apoptotic, anti-inflammatory and anti-carcinogenic activities. Aggressive marketing of such health promoting benefits has resulted in mangosteen’s classification as a “superfruit”. This has led to sales of mangosteen containing beverages in USA alone exceeding $200 million in 2008 despite very limited animal and human studies. This review will (a) critically address recent reports of in vivo studies on the bioavailability and metabolism of mangosteen xanthones, (b) update the in vitro and in vivo data on anti-cancer and anti-inflammatory activities of mangosteen xanthones, and (c) suggest needed areas of inquiry regarding the absorption, metabolism and efficacy of mangosteen xanthones.
          Article 0 comments Cited 61 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Tetraoxygenated naturally occurring xanthones.

            Valdir Peres, Tanus Jorge NAGEM, Fernando Faustino de Oliveira (2000)
            This review, with 350 references, gives information on the chemical study of 234 naturally occurring tetraoxygenated xanthones in 12 families, 53 genus and 182 species of higher plants, and two which are described as fungal and lichen metabolites. The value of these groups of substances in connection with pharmacological activity and therapeutic use of some species is described. The structural formulas of 135 isolated compounds, and their distribution, are also given.
            Article 0 comments Cited 46 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Caged Garcinia xanthones: development since 1937.

              Simon Han, Hong-Xi Xu (2009)
              Caged xanthones, characterized by a unique 4-oxa-tricyclo[4.3.1.0(3,7)]dec-2-one scaffold, are a special class of bioactive components mainly derived from the Garcinia genus (Guttiferae family). Around 100 compounds from this family have been reported to date and most of them have potent antitumor activity, with gambogic acid being the best representative. During the past decades, inspired by the unusual caged skeleton and remarkable bioactivity, scientists from various fields have shown increasing interest on these promising natural products. In this review, the plant resources, structural characteristics, total synthesis, biological activity and mechanisms of action, structure activity relationship, and anticancer drug development of these caged xanthones are described.
              Article 0 comments Cited 34 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Molecules
                Journal ID (iso-abbrev): Molecules
                Journal ID (publisher-id): molecules
                Title: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
                Publisher: MDPI
                ISSN (Electronic): 1420-3049
                Publication date (Electronic): 11 October 2017
                Publication date Collection: October 2017
                Volume: 22
                Issue: 10
                Electronic Location Identifier: 1698
                Affiliations
                [1 ]Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China; Ruanjy19930919@ 123456163.com (J.R.); 18702270347@ 123456163.com (C.Z.); liuyanxia210@ 123456163.com (Y.L.)
                [2 ]Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshan Road, Nankai District, Tianjin 300193, China; qululuhan88@ 123456163.com (L.Q.); yuhaiyang19830116@ 123456hotmail.com (H.Y.); hanlifeng_1@ 123456163.com (L.H.)
                Author notes
                [* ]Correspondence: zhwwxzh@ 123456263.net (Y.Z.); wangtao@ 123456tjutcm.edu.cn (T.W.); Tel./Fax: +86-22-5959-6163 (Y.Z. & T.W.)
                Article
                Publisher ID: molecules-22-01698
                DOI: 10.3390/molecules22101698
                PMC ID: 6151445
                PubMed ID: 29019929
                SO-VID: 851161c9-2312-4294-bc72-79bc6b127ce8
                Copyright © © 2017 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 11 September 2017
                Date accepted : 09 October 2017
                Categories
                Subject: Review

                Keywords: herbal medicines,xanthones,plant sources,pharmacology,gambogic acid,structure-activity relationships
                Data availability:
                Keywords: herbal medicines, xanthones, plant sources, pharmacology, gambogic acid, structure-activity relationships

                Comments

                Comment on this article

                scite_

                Similar content212

                See all similar

                Cited by9

                See all cited by

                Most referenced authors2,027

                See all reference authors