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Abstract
<p class="first" id="d745737e71">Cancer immunotherapy is a validated and critically
important approach for treating
patients with cancer. Given the vast research and clinical investigation efforts dedicated
to advancing both endogenous and synthetic immunotherapy approaches, there is a need
to focus on crucial questions and define roadblocks to the basic understanding and
clinical progress. Here, we define ten key challenges facing cancer immunotherapy,
which range from lack of confidence in translating pre-clinical findings to identifying
optimal combinations of immune-based therapies for any given patient. Addressing these
challenges will require the combined efforts of basic researchers and clinicians,
and the focusing of resources to accelerate understanding of the complex interactions
between cancer and the immune system and the development of improved treatment options
for patients with cancer.
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