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      Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds

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          Abstract

          Tragopogon graminifolius DC. is a perennial plant from the family Asteraceae which grows in West parts of Iran. Several biological activities like antimicrobial, antioxidant and anti-inflammatory effects are reported for the plant. The aim of this study was to assess the wound healing activity of standardized extract from T. graminifolius (TG) aerial parts. Topical standardized TG extract with 5% and 10% concentrations in eucerine base was assessed for its healing properties on second degree burn in rats during a 14-day period. Biomarkers of oxidative damage including total antioxidant power, lipid peroxidation and total thiol molecules of the skin tissue samples were also evaluated. Results showed that 10%TG had the best efficacy with 80 ± 3% wound closure and tissue repair in comparison to negative control (p < 0.05). Significant reduction of tissue oxidative stress biomarkers was also observed. Histological analyses confirmed wound healing activity of TG extract, as well. Considering the antioxidative stress and anti-inflammatory activities of TG, explained by the high content of phenolic compounds of the plant, standardized TG extract could be considered as a natural remedy for the treatment of burn wounds. Further clinical studies are suggested to confirm the effectiveness of TG as a wound healing agent.

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          Oxidative stress in normal and impaired wound repair.

          Matthias Schäfer, Sabine Werner (2008)
          A large percentage of the population suffers from wound healing abnormalities, in particular aged individuals, patients with diabetes, and those treated with immunosuppressive drugs, chemo- or radiotherapy. The mechanisms underlying the impaired healing response are still poorly understood. Recent studies provided strong evidence for a role of oxidative stress in the pathogenesis of non-healing ulcers. Therefore, it is of major importance to identify and functionally characterize the factors involved in the generation and detoxification of reactive oxygen species (ROS). This will provide the basis for the development of new strategies for therapeutic intervention. In this review we summarize the current information about the roles of low molecular weight antioxidants and ROS-detoxifying enzymes in normal and impaired wound repair, and we report on the consequences of their modulation at the wound site.
          Article 0 comments Cited 242 times – based on 0 reviews     Review now
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            Ethnopharmacological approaches to wound healing--exploring medicinal plants of India.

            R Govindarajan, B. V. N. Phani Kumar, M Vijayakumar … (2007)
            India has a rich tradition of plant-based knowledge on healthcare. A large number of plants/plant extracts/decoctions or pastes are equally used by tribals and folklore traditions in India for treatment of cuts, wounds, and burns. The present review thus attempts to analyze the ethnobotanical knowledge base for treatment of cuts and wounds which includes a usage of plants, methods employed by tribals and folklore practices prevailing in India. Pharmacological reports available on Indian medicinal plants employing various wound healing models and its underlying molecular mechanism, wherever available, has also been briefly reviewed. This pharmacological validation on Indian medicinal plants is very limited and a large number of plants used in tribal and folklore with enormous potential have not been validated for their wound healing activity. This review therefore attempts to bridge the lacunae in the existing literature and offers immense scope for researchers engaged in validation of the traditional claims and development of safe and effective and globally accepted herbal drugs for cuts and wounds.
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              Antioxidant Therapies for Wound Healing: A Clinical Guide to Currently Commercially Available Products

              S.D. Fitzmaurice, R.K. Sivamani, R.R. Isseroff (2011)
              Many facets of wound healing under redox control require a delicate balance between oxidative stress and antioxidants. While the normal physiology of wound healing depends on low levels of reactive oxygen species and oxidative stress, an overexposure to oxidative stress leads to impaired wound healing. Antioxidants are postulated to help control wound oxidative stress and thereby accelerate wound healing. Many antioxidants are available over the counter or by prescription, but only one, Medihoney®, has been specifically FDA approved for wound healing. Here we review the existing evidence for the use of antioxidants for wound healing, with a review of the pertinent animal and clinical studies. Natural products and naturally derived antioxidants are becoming more popular, and we specifically review the evidence for the use of naturally derived antioxidants in wound healing. Antioxidant therapy for wound healing is promising, but only few animal studies and even fewer clinical studies are available. Because only few products have undergone FDA approval, the consumer is advised to scrutinize them for purity and contaminants prior to use, and this may require direct contact with the companies that sell them. As a field of science, the use of antioxidants for wound healing is in its infancy, and future studies will better elucidate the role of antioxidants in wound healing.
              Article 0 comments Cited 70 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Mohammad Hosein Farzaei
                Journal
                Journal ID (nlm-ta): J Tradit Complement Med
                Journal ID (iso-abbrev): J Tradit Complement Med
                Title: Journal of Traditional and Complementary Medicine
                Publisher: Elsevier
                ISSN (Electronic): 2225-4110
                Publication date PMC-release: 27 April 2018
                Publication date Collection: January 2019
                Publication date (Electronic): 27 April 2018
                Volume: 9
                Issue: 1
                Pages: 54-59
                Affiliations
                [a ]Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
                [b ]Department of Pharmaceutics, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
                [c ]Department of Pharmacy in Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
                [d ]Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
                [e ]Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
                [f ]Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
                [g ]Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
                [h ]Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
                Author notes
                [∗ ]Corresponding author. Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. mh.farzaei@ 123456gmail.com
                Article
                Publisher ID: S2225-4110(18)30012-9
                DOI: 10.1016/j.jtcme.2018.02.002
                PMC ID: 6335475
                PubMed ID: 30671366
                SO-VID: 834280d2-f772-4a1d-9101-4dd777902eeb
                Copyright © © 2018 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC.
                License:

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                Date received : 13 February 2017
                Date revision received : 26 January 2018
                Date accepted : 18 February 2018
                Categories
                Subject: Original Article

                Keywords: tragopogon graminifolius,second-degree burn,oxidative stress,medicinal plant
                Data availability:
                Keywords: tragopogon graminifolius, second-degree burn, oxidative stress, medicinal plant

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