7
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      H3K27M-mutant glioma in thoracic spinal cord and conus medullaris with pilocytic astrocytoma morphology: case report and review of the literature

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Related collections

          Most cited references2

          • Record: found
          • Abstract: found
          • Article: found

          Prolonged survival in a patient with a cervical spine H3K27M-mutant diffuse midline glioma.

          We report a case of prolonged survival in a patient with known cervical intramedullary H3K27M-mutant diffuse midline glioma. A 39-year-old man presented for evaluation with several months of progressive upper extremity pain and weakness. MRI of the cervical spine revealed an intramedullary ring-enhancing lesion centred at C3-C4. Following subtotal surgical resection, a diagnosis of glioblastoma (GBM) was confirmed. Subsequent testing at a later date revealed an H3K27M mutation. He was initially treated with radiation and concomitant and adjuvant temozolomide. He had multiply recurrent disease and was treated with various regimens, including the histone deacetylase inhibitor valproic acid. The patient passed away 31 months (~2.5 years) after diagnosis. Our case is one of few reported adult spinal cord GBMs possessing the H3K27M mutation, and one with the longest reported overall survival in the literature to date.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: found

            Tectal Low-Grade Glioma with H3 K27M Mutation.

            In the revised World Health Organization 2016 classification of central nervous system tumors, "diffuse midline glioma, H3 K27M-mutant" has been added as a new diagnostic entity. However, some confusion exists concerning this diagnostic entity because H3 K27M-mutant diffuse midline glioma is diagnosed with grade IV regardless of morphologic phenotype. Furthermore, the significance of H3 K27M mutation in tumors that aren't typical "diffuse midline glioma, H3 K27M-mutant," such as those with an unusual location and nontypical histology, remains unclear.
              Bookmark

              Author and article information

              Contributors
              (View ORCID Profile)
              Journal
              British Journal of Neurosurgery
              British Journal of Neurosurgery
              Informa UK Limited
              0268-8697
              1360-046X
              October 07 2021
              : 1-7
              Affiliations
              [1 ]Department of Neurosurgery, La Paz University Hospital, Madrid, Spain
              [2 ]Department of Pathology, La Paz University Hospital, Madrid, Spain
              Article
              10.1080/02688697.2021.1988054
              34615413
              8134d49a-39a7-47a8-85f3-8b4193c10acd
              © 2021
              History

              Comments

              Comment on this article