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Abstract
Posterior capsule opacification (PCO) remains the most common long-term complication
after cataract surgery. Many studies have attempted to identify factors that influence
the development of PCO. The aim of this systematic review based on Cochrane methodology
was to summarize the effects of intraocular lens (IOL) geometry, including modifications
of the IOL optic (especially optic edge design) and haptics, on the development of
PCO. Twenty-six prospective randomized controlled trials with a follow-up of at least
12 months were included. In 5 of 7 studies, visual acuity was better in sharp-edged
IOLs than in round-edged IOL. The PCO score was significantly lower with sharp-edged
IOLs but did not differ significantly between 1-piece and 3-piece open-loop IOLs.
Because of the significant difference in the PCO score, sharp-edged IOL optics should
be preferred to round-edged IOL optics.