Uterine contractions in rodent models and humans

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Aberrant uterine contractions can lead to preterm birth and other labour complications and are a significant cause of maternal morbidity and mortality. To investigate the mechanisms underlying dysfunctional uterine contractions, researchers have used experimentally tractable small animal models. However, biological differences between humans and rodents change how researchers select their animal model and interpret their results. Here, we provide a general review of studies of uterine excitation and contractions in mice, rats, guinea pigs, and humans, in an effort to introduce new researchers to the field and help in the design and interpretation of experiments in rodent models.

Related collections

Most cited references 176

Record: found
Abstract: found
Article: not found

Is Open Access

Global causes of maternal death: a WHO systematic analysis.

Lale Say, Doris Chou, Alison Gemmill … (2014)

Data for the causes of maternal deaths are needed to inform policies to improve maternal health. We developed and analysed global, regional, and subregional estimates of the causes of maternal death during 2003-09, with a novel method, updating the previous WHO systematic review. We searched specialised and general bibliographic databases for articles published between between Jan 1, 2003, and Dec 31, 2012, for research data, with no language restrictions, and the WHO mortality database for vital registration data. On the basis of prespecified inclusion criteria, we analysed causes of maternal death from datasets. We aggregated country level estimates to report estimates of causes of death by Millennium Development Goal regions and worldwide, for main and subcauses of death categories with a Bayesian hierarchical model. We identified 23 eligible studies (published 2003-12). We included 417 datasets from 115 countries comprising 60 799 deaths in the analysis. About 73% (1 771 000 of 2 443 000) of all maternal deaths between 2003 and 2009 were due to direct obstetric causes and deaths due to indirect causes accounted for 27·5% (672 000, 95% UI 19·7-37·5) of all deaths. Haemorrhage accounted for 27·1% (661 000, 19·9-36·2), hypertensive disorders 14·0% (343 000, 11·1-17·4), and sepsis 10·7% (261 000, 5·9-18·6) of maternal deaths. The rest of deaths were due to abortion (7·9% [193 000], 4·7-13·2), embolism (3·2% [78 000], 1·8-5·5), and all other direct causes of death (9·6% [235 000], 6·5-14·3). Regional estimates varied substantially. Between 2003 and 2009, haemorrhage, hypertensive disorders, and sepsis were responsible for more than half of maternal deaths worldwide. More than a quarter of deaths were attributable to indirect causes. These analyses should inform the prioritisation of health policies, programmes, and funding to reduce maternal deaths at regional and global levels. Further efforts are needed to improve the availability and quality of data related to maternal mortality. © 2014 World Health Organization; licensee Elsevier. This is an Open Access article published without any waiver of WHO's privileges and immunities under international law, convention, or agreement. This article should not be reproduced for use in association with the promotion of commercial products, services, or any legal entity. There should be no suggestion that WHO endorses any specific organisation or products. The use of the WHO logo is not permitted. This notice should be preserved along with the article's original URL.

0 comments Cited 1434 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: found

Is Open Access

Global, regional, and national causes of under-5 mortality in 2000–15: an updated systematic analysis with implications for the Sustainable Development Goals

Li Liu, Shefali Oza, Dan Hogan … (2016)

Summary Background Despite remarkable progress in the improvement of child survival between 1990 and 2015, the Millennium Development Goal (MDG) 4 target of a two-thirds reduction of under-5 mortality rate (U5MR) was not achieved globally. In this paper, we updated our annual estimates of child mortality by cause to 2000–15 to reflect on progress toward the MDG 4 and consider implications for the Sustainable Development Goals (SDG) target for child survival. Methods We increased the estimation input data for causes of deaths by 43% among neonates and 23% among 1–59-month-olds, respectively. We used adequate vital registration (VR) data where available, and modelled cause-specific mortality fractions applying multinomial logistic regressions using adequate VR for low U5MR countries and verbal autopsy data for high U5MR countries. We updated the estimation to use Plasmodium falciparum parasite rate in place of malaria index in the modelling of malaria deaths; to use adjusted empirical estimates instead of modelled estimates for China; and to consider the effects of pneumococcal conjugate vaccine and rotavirus vaccine in the estimation. Findings In 2015, among the 5·9 million under-5 deaths, 2·7 million occurred in the neonatal period. The leading under-5 causes were preterm birth complications (1·055 million [95% uncertainty range (UR) 0·935–1·179]), pneumonia (0·921 million [0·812 −1·117]), and intrapartum-related events (0·691 million [0·598 −0·778]). In the two MDG regions with the most under-5 deaths, the leading cause was pneumonia in sub-Saharan Africa and preterm birth complications in southern Asia. Reductions in mortality rates for pneumonia, diarrhoea, neonatal intrapartum-related events, malaria, and measles were responsible for 61% of the total reduction of 35 per 1000 livebirths in U5MR in 2000–15. Stratified by U5MR, pneumonia was the leading cause in countries with very high U5MR. Preterm birth complications and pneumonia were both important in high, medium high, and medium child mortality countries; whereas congenital abnormalities was the most important cause in countries with low and very low U5MR. Interpretation In the SDG era, countries are advised to prioritise child survival policy and programmes based on their child cause-of-death composition. Continued and enhanced efforts to scale up proven life-saving interventions are needed to achieve the SDG child survival target. Funding Bill & Melinda Gates Foundation, WHO.

0 comments Cited 1042 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Pregnancy-Related Mortality in the United States, 2011–2013

Andreea A. Creanga, Carla Syverson, Kristi Seed … (2017)

To update national population-level pregnancy-related mortality estimates and examine characteristics and causes of pregnancy-related deaths in the United States during 2011-2013.

0 comments Cited 239 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Sarah K. England:

ORCID: https://orcid.org/0000-0003-4247-0281

englands@wustl.edu

Journal

Journal ID (nlm-ta): Acta Physiol (Oxf)

Journal ID (iso-abbrev): Acta Physiol (Oxf)

Journal ID (doi): 10.1111/(ISSN)1748-1716

Journal ID (publisher-id): APHA

Title: Acta Physiologica (Oxford, England)

Publisher: John Wiley and Sons Inc. (Hoboken )

ISSN (Print): 1748-1708

ISSN (Electronic): 1748-1716

Publication date (Electronic): 07 January 2021

Publication date (Print): April 2021

Volume: 231

Issue: 4 ( doiID: 10.1111/apha.2021.231.issue-4 )

Electronic Location Identifier: e13607

Affiliations

[ ¹ ] Center for Reproductive Health Sciences Department of Obstetrics and Gynecology Washington University School of Medicine St. Louis MO USA

Author notes

[*] [* ] Correspondence

Sarah K. England, Center for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University School of Medicine, 425 South Euclid Avenue, Campus Box 8064, St. Louis, MI 63110, USA.

Email: englands@ 123456wustl.edu

Author information

Manasi Malik https://orcid.org/0000-0002-4203-962X

Sarah K. England https://orcid.org/0000-0003-4247-0281

Article

Publisher ID: APHA13607

DOI: 10.1111/apha.13607

PMC ID: 8047897

PubMed ID: 33337577

SO-VID: 7fbe6ccb-ca2b-407d-bc18-f06dc64511c3

License:

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

History

Date revision received : 07 December 2020

Date received : 17 August 2020

Date accepted : 11 December 2020

Page count

Figures: 3, Tables: 3, Pages: 17, Words: 12245

Funding

Funded by: Eunice Kennedy Shriver National Institute of Child Health and Human Development , open-funder-registry 10.13039/100009633;

Award ID: F30 HD097925

Award ID: R01 HD037831

Award ID: R01 HD088097

Award ID: R01 HD096737

Funded by: Corteva Agriscience , open-funder-registry 10.13039/100015614;

Funded by: March of Dimes Foundation , open-funder-registry 10.13039/100000912;

Award ID: #6‐FY18‐664

Custom metadata

source-schema-version-number 2.0

cover-date April 2021

details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:6.0.2 mode:remove_FC converted:15.04.2021

ScienceOpen disciplines: Anatomy & Physiology

Keywords: animal models,contraction,myometrium,parturition,pregnancy,species differences,uterus

Data availability:

ScienceOpen disciplines: Anatomy & Physiology

Keywords: animal models, contraction, myometrium, parturition, pregnancy, species differences, uterus

Comments

Comment on this article

scite_

Smart Citations

Citing PublicationsSupportingMentioningContrasting

View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

Cited by 16

See all cited by

Most referenced authors 1,431

See all reference authors

Uterine contractions in rodent models and humans

Read this article at

Abstract

Related collections

In vitro alveolar region models

Most cited references 176

Global causes of maternal death: a WHO systematic analysis.

Global, regional, and national causes of under-5 mortality in 2000–15: an updated systematic analysis with implications for the Sustainable Development Goals

Pregnancy-Related Mortality in the United States, 2011–2013

Author and article information

Contributors

Journal

Affiliations

Author notes

Author information

Article

History

Page count

Funding

Categories

Custom metadata

Comments

Comment on this article

Similar content 994

Cited by 16

Most referenced authors 1,431