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Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjects.

Author(s): Nora D. Volkow, A Kriplani, Thalia R. Goldstein, Rohan Benjamin Hugh Williams, Joanna Fowler, Jean Logan, Jack Wang, P Vaska, Nelly Alia-Klein, Wei Zhu, P. I. Craig, Frank Telang

Publication date: 2007-08-15

Journal: Biological Psychiatry

Keywords: Adult, Brain, drug effects, enzymology, radionuclide imaging, Brain Mapping, Carbon Radioisotopes, metabolism, Clorgyline, pharmacology, Humans, Male, Minisatellite Repeats, genetics, Monoamine Oxidase, Monoamine Oxidase Inhibitors, Positron-Emission Tomography, Radiopharmaceuticals, Reference Values

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Abstract

A functional polymorphism in the promoter region of the monoamine oxidase A (MAO A) gene has two common alleles that are referred to as the high and low MAO A genotypes. We report the first in vivo human study to determine whether there is an association between MAO A genotype and brain MAO A activity in healthy male subjects. Brain MAO A activity was measured with positron emission tomography and [(11)C]clorgyline in 38 healthy adult male nonsmokers genotyped for MAO A polymorphism. There was no significant difference in brain MAO A activity between the high (n = 26) and low (n = 12) MAO A genotypes. The lack of an association between the high and low MAO A genotype and brain MAO A activity suggests that this polymorphism by itself does not contribute to differences in brain MAO A activity in healthy adult male subjects.

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PubMed ID:: 17141746

PMC ID:: 2712611

DOI:: 10.1016/j.biopsych.2006.08.038

ScienceOpen disciplines: Chemistry

Keywords: Adult,Brain,drug effects,enzymology,radionuclide imaging,Brain Mapping,Carbon Radioisotopes,metabolism,Clorgyline,pharmacology,Humans,Male,Minisatellite Repeats,genetics,Monoamine Oxidase,Monoamine Oxidase Inhibitors,Positron-Emission Tomography,Radiopharmaceuticals,Reference Values

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ScienceOpen disciplines: Chemistry

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