Prebiotic galacto-oligosaccharides mitigate the adverse effects of iron fortification on the gut microbiome: a randomised controlled study in Kenyan infants.

Zimmermann, Michael B.; Paganini, Daniela; Uyoga, Mary A.; Kortman, Guus A. M.; Cercamondi, Colin I.; Moretti, Diego; Barth-Jaeggi, Tanja; Schwab, Clarissa; Boekhorst, Jos; Timmerman, Harro M; Lacroix, Christophe

doi:10.1136/gutjnl-2017-314418

Record: found
Abstract: found
Article: not found

Prebiotic galacto-oligosaccharides mitigate the adverse effects of iron fortification on the gut microbiome: a randomised controlled study in Kenyan infants.

Author(s): Daniela Paganini ¹ , Mary A Uyoga ² , Guus A M Kortman ³ , Colin I Cercamondi ¹ , Diego Moretti ¹ , Tanja Barth-Jaeggi ⁴ , Clarissa Schwab ¹ , Jos Boekhorst ³ , Harro M Timmerman ³ , Christophe Lacroix ¹ , Simon Karanja ² , Michael B Zimmermann ¹

Publication date (Electronic): Nov 2017

Journal: Gut

Publisher: BMJ

Keywords: anemia, diarrhea, enteric pathogens, gut, infancy, iron deficiency, kenya, microbiome, micronutrient powder, prebiotic

Read this article at

ScienceOpenPublisher PubMed

Bookmark

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Iron-containing micronutrient powders (MNPs) reduce anaemia in African infants, but the current high iron dose (12.5 mg/day) may decrease gut Bifidobacteriaceae and Lactobacillaceae, and increase enteropathogens, diarrhoea and respiratory tract infections (RTIs). We evaluated the efficacy and safety of a new MNP formula with prebiotic galacto-oligosaccharides (GOS) combined with a low dose (5 mg/day) of highly bioavailable iron.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Gut

Title: Gut

Publisher: BMJ

ISSN (Electronic): 1468-3288

ISSN (Print): 0017-5749

Publication date (Electronic): Nov 2017

Volume: 66

Issue: 11

Affiliations

[1 ] Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.

[2 ] Department of Medical Epidemiology, College of Health Sciences, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya.

[3 ] NIZO Food Research BV, Ede, The Netherlands.

[4 ] Health Systems Support Unit, Swiss Tropical and Public Health Institute, Basel, Switzerland.

Article

Publisher Item ID: gutjnl-2017-314418

DOI: 10.1136/gutjnl-2017-314418

PubMed ID: 28774885

SO-VID: 7f48084d-3abb-4287-a0c1-a9a4bb0ac365

History

Keywords: infancy,diarrhea,enteric pathogens,gut,iron deficiency,kenya,microbiome,micronutrient powder,prebiotic,anemia

Data availability:

Keywords: infancy, diarrhea, enteric pathogens, gut, iron deficiency, kenya, microbiome, micronutrient powder, prebiotic, anemia

Prebiotic galacto-oligosaccharides mitigate the adverse effects of iron fortification on the gut microbiome: a randomised controlled study in Kenyan infants.

Read this article at

Abstract

Related collections

Role of Microbes in Soil Fertility and Human Health

Author and article information

Journal

Affiliations

Article

History

Comments

Comment on this article

Similar content 316

Cited by 73