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Toward the blood-borne miRNome of human diseases.

Author(s): U Jäger, Jan Haas, Johannes Dietl, Junko Huebers, Stefan Schreiber, Benjamin Meder, Sylvia Hofmann, J Wischhusen, Andrea Bauer, Nathalia Giese, Norbert Graf, Markus W. Büchler, J Hoheisel, Abdou ElSharawy, Arne Schaefer, Britta Vogel, Hanno Huwer, Bastian Keck, Andreas Keller, J. Reichrath, Wolfgang Rottbauer, Katja Ott, Christina Backes, Philip Rosenstiel, H Katus, Valesca Boisguerin, Peer Staehler, Christine Tjaden, Jens Werner, Almut Nebel, Bernd Wullich, Hans-Peter Lenhof, Gunnar Jacobs, Klemens Ruprecht, ANKE WENDSCHLAG, Cord Staehler, Thilo Hackert, Sebastian Haeusler, Joachim Müller-Quernheim, Petra Leidinger, Matthias Scheffler, Andre Franke, Ioannis Amarantos, Henrik Dommisch, Eckart Meese, Markus Beier

Publication date: 2010-12-31

Journal: Nature Methods

Keywords: Disease, genetics, Gene Expression Profiling, Genetic Variation, Humans, MicroRNAs, blood, Oligonucleotide Array Sequence Analysis, Reverse Transcriptase Polymerase Chain Reaction

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Abstract

In a multicenter study, we determined the expression profiles of 863 microRNAs by array analysis of 454 blood samples from human individuals with different cancers or noncancer diseases, and validated this 'miRNome' by quantitative real-time PCR. We detected consistently deregulated profiles for all tested diseases; pathway analysis confirmed disease association of the respective microRNAs. We observed significant correlations (P = 0.004) between the genomic location of disease-associated genetic variants and deregulated microRNAs.

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PubMed ID:: 21892151

DOI:: 10.1038/nmeth.1682

ScienceOpen disciplines: Chemistry

Keywords: Disease,genetics,Gene Expression Profiling,Genetic Variation,Humans,MicroRNAs,blood,Oligonucleotide Array Sequence Analysis,Reverse Transcriptase Polymerase Chain Reaction

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ScienceOpen disciplines: Chemistry

Keywords: Disease, genetics, Gene Expression Profiling, Genetic Variation, Humans, MicroRNAs, blood, Oligonucleotide Array Sequence Analysis, Reverse Transcriptase Polymerase Chain Reaction

Toward the blood-borne miRNome of human diseases.

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