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Toward the blood-borne miRNome of human diseases
Andreas Keller ,
Petra Leidinger ,
Andrea Bauer ,
Abdou ElSharawy ,
Jan Haas ,
Christina Backes ,
Anke Wendschlag ,
Nathalia Giese ,
Christine Tjaden ,
Katja Ott ,
Jens Werner ,
Thilo Hackert ,
Klemens Ruprecht ,
Hanno Huwer ,
Junko Huebers ,
Gunnar Jacobs ,
Philip Rosenstiel ,
Henrik Dommisch ,
Arne Schaefer ,
Joachim Müller-Quernheim ,
Bernd Wullich ,
Bastian Keck ,
Norbert Graf ,
Joerg Reichrath ,
Britta Vogel ,
Almut Nebel ,
Sven U Jager ,
Peer Staehler ,
Ioannis Amarantos ,
Valesca Boisguerin ,
Cord Staehler ,
Markus Beier ,
Matthias Scheffler ,
Markus W Büchler ,
Joerg Wischhusen ,
Sebastian F M Haeusler ,
Johannes Dietl ,
Sylvia Hofmann ,
Hans-Peter Lenhof ,
Stefan Schreiber ,
Hugo A Katus ,
Wolfgang Rottbauer ,
Benjamin Meder ,
Joerg D Hoheisel ,
Andre Franke ,
Eckart Meese
September 4 2011
September 4 2011
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Abstract
In a multicenter study, we determined the expression profiles of 863 microRNAs by
array analysis of 454 blood samples from human individuals with different cancers
or noncancer diseases, and validated this 'miRNome' by quantitative real-time PCR.
We detected consistently deregulated profiles for all tested diseases; pathway analysis
confirmed disease association of the respective microRNAs. We observed significant
correlations (P = 0.004) between the genomic location of disease-associated genetic
variants and deregulated microRNAs.