Clinical Relevance of Posttransplant DSAs in Patients Receiving Desensitization for HLA-incompatible Kidney Transplantation.

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Abstract

Highly HLA-sensitized (HS) patients have an increased risk for the development of donor-specific antibodies (DSA) and antibody-mediated rejection (AMR) posttransplant. Here, we examined the risk for AMR in HS patients transplanted after desensitization (DES) who were DSA+ versus DSA- at transplant. We also examined the incidence and clinical impact of de novo DSAs (dnDSAs) and compared with dnDSA- patients.

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Journal

Journal ID (iso-abbrev): Transplantation

Title: Transplantation

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1534-6080

ISSN (Print): 0041-1337

Publication date (Electronic): December 2019

Volume: 103

Issue: 12

Affiliations

[1 ] Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.

[2 ] Paris Translational Research Center for Organ Transplantation, INSERM U970, Biostatistics Department, Paris, France.

[3 ] Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA.

[4 ] Department of HLA and Immunogenetics Lab, Cedars-Sinai Medical Center, Los Angeles, CA.

Article

DOI: 10.1097/TP.0000000000002691

PubMed ID: 30883456

SO-VID: 7b2676f6-6e83-4035-b721-06f81c33f4e7

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