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Abstract
Cell polarity, the generation of cellular asymmetries, is necessary for diverse processes
in animal cells, such as cell migration, asymmetric cell division, epithelial barrier
function, and morphogenesis. Common mechanisms generate and transduce cell polarity
in different cells, but cell type-specific processes are equally important. In this
review, we highlight the similarities and differences between the polarity mechanisms
in eggs and epithelia. We also highlight the prospects for future studies on how cortical
polarity interfaces with other cellular processes, such as morphogenesis, exocytosis,
and lipid signaling, and how defects in polarity contribute to tumor formation.
Copyright 2010 Elsevier Inc. All rights reserved.