Bangladesh is listed among the 57 human resource for health (HRH) crisis countries
as identified by the Global Health Workforce Alliance.1, 2 Despite shortages and maldistribution
of health-care personnel, Bangladesh was known for successful immunisation campaigns
even before the COVID-19 pandemic.
3
The COVID-19 vaccination drive initially was not smooth for Bangladesh, but the country
has, since July 2021, regained its reputation for strong vaccination efforts. COVID-19
vaccination started on Feb 7, 2021, with the ChAdOx1-nCoV-19 vaccine known as Covishield,
(Serum Institute India [SII]). Vaccination was initially postponed while the SII suspended
the export of vaccines as the number of COVID-19 infections in India increased. The
Government of Bangladesh, however, managed to procure vaccines from alternative sources,
which helped to alleviate its dependency on a single source. The Government intends
to administer four different vaccines (Covishield, BBIBP-CorV [Sinopharm], Comirnaty
[Pfizer-BioNTech], and Spikevax [Moderna]) to 170 million people in Bangladesh. As
of December 13, 2021, Bangladesh has administered 86·5 million first doses and 43·3
million second doses (figure
),
4
equating to roughly 50% of the total Bangladeshi population having received at least
one dose and roughly 25% having been administered two doses of COVID-19 vaccines.
Despite vaccine hesitancy and commonly held misconceptions about vaccines globally,
vaccine acceptance among this population is encouraging. Like other low-income and
middle-income countries (LMIC), Bangladesh has been supported by COVAX, which is co-led
by the Coalition for Epidemic Preparedness Innovations, Gavi, the Vaccine Alliance,
WHO, and UNICEF to ensure equitable access to COVID-19 vaccines. After Indonesia,
COVAX vaccine roll-out in Bangladesh ranks second highest among southeast Asian countries.
This achievement is a monumental feat for Bangladesh given that high-income countries
have already administered 69 times more doses than Bangladesh, showing a stratified
and inequitable vaccine procurement and roll-out.
5
Figure
COVID-19 vaccination profile in Bangladesh as of December 13, 2021
Tedros Adhanom Ghebreyesus, Director-General of WHO, notes that inequitable global
distribution of the COVID-19 vaccine will burden LMICs most, resulting in a catastrophic
moral failure.
6
The possibility of this moral failure accentuates the importance of sharing technologies
among manufacturers to enhance the capacity of vaccine manufacturing facilities in
LMICs, which could then allow vaccines to be manufactured locally and complement global
efforts to ensure equitable COVID-19 vaccine supply. Both Bangladeshi Prime Minister
Sheikh Hasina and Muhammad Yunus, the only Nobel Laureate in Peace (2006) from Bangladesh,
have been instrumental in a campaign to declare COVID-19 vaccines a global common
good. This endeavour is a joint appeal from 3000 people including international personalities,
Nobel Laureates, global leaders, international organisations, pharmaceutical companies,
and governments.
7
In addition to procuring vaccines from a diverse portfolio of manufacturers, Bangladesh
has adopted a model to become self-reliant in vaccine manufacturing. A Bangladeshi
biotech company, Globe Biotech, has completed non-human primate trials of its own
mRNA-based vaccine and received approval for human trials.
8
Additionally, other Bangladeshi vaccine manufacturing companies are capable of addressing
the void in vaccine antigen production. Experts predict that the global COVID-19 vaccine
supply could be substantially increased if vaccine manufacturers would share their
efforts and technological knowledge with external manufacturers capable of vaccine
production.
5
For example, Incepta Vaccine Limited (IVL), the largest human vaccine manufacturing
facility in Bangladesh, has signed a memorandum of understanding with Sinopharm, China,
for production of the Sinopharm BBIBP-COVID-19 vaccine in Bangladesh. This collaboration
will undoubtedly expedite the efforts of Bangladesh to produce viable COVID-19 vaccines
in local settings. Along with contract manufacturing, IVL is also in the race to develop
its own research and development based COVID-19 vaccine in collaboration with international
institutes.
9
Furthermore, Bangladesh has agreed to participate in a clinical trial for a novel
nasal-route COVID-19 vaccine, developed by Karolinska Institute, Sweden.
With the increasing concern of waning vaccine immunity
10
and effective results from heterologous vaccine priming and boosting,11, 12 Bangladesh
should determine its policy and act quickly. Bangladesh has local vaccine research
and production capacity at its disposal, along with four distinct COVID-19 vaccines.
Looking forward, Bangladesh should focus on hosting clinical trials, including heterologous
prime boost trials, to determine vaccine efficacy and long-term protection for its
population. Although there is a debate on whether to administer a third vaccine dose
as booster, evidence to support recommended schedules and target groups is scarce.
13
A third dose for individuals who have already received two doses should be carefully
considered only after two doses of the vaccine have been administered to the remaining
unvaccinated people. To ensure maximum vaccine coverage, countries such as Bangladesh
should allocate resources to local manufacturers and support large-scale research
efforts, clinical trials, cold-chain technology, and international collaboration.
Support could be in the form of subsidies, duty-free import of research items, or
tax incentives for vaccine manufacturers and research organisations.
To bring this pandemic under control, more than 75% of the global population must
be vaccinated.
14
This goal becomes increasingly challenging given the unequal distribution and hoarding
of vaccines by high-income countries. This inequality could be obviated, however,
by strict adherence to the procurement and supply operation under the COVAX initiative.
This mandate should serve as a reference for ensuring equitable global access to the
COVID-19 vaccine. Discrete high vaccination performance and travel bans from high-income
countries will not only be futile in bringing the pandemic under control but will
also put all nations at risk unless the global population is universally vaccinated.
15
Initiatives should be undertaken to acquire and distribute vaccines among LMICs. Without
such initiatives there remains a growing concern for the persistent presence of COVID-19
hot spots in low-income countries, which increases the risk of escape variants of
SARS-COV-2.
We declare no competing interests. We would like to acknowledge Nikki Kelvin for editing
this manuscript. This work was supported by grants from Canadian Institutes of Health
Research, Genome Canada/Atlantic Genome, Research Nova Scotia, Dalhousie Medical Research
Foundation, and the Li-Ka Shing Foundation.