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Abstract
Polysaccharide-based hydrogels are remarkable materials for the biomedical fields
because of its excellent biodegradation and biocompatibility. In this work, a novel
polysaccharide-based hydrogel was fabricated by in situ crosslinking of starch-based
nanoparticles and polyvinylamine. Starch was decorated with cholesterol group and
aldehyde groups. TEM and DLS showed that the cholesterol modified oxidation starch
(OCS) exhibited a core-shell nanoparticles with mean size of ∼143 nm in aqueous. The
hydrogel was then synthesized via Schiff base reaction. Rheological measurements demonstrated
the incorporation of cholesterol groups not only reduced the gel time but also improved
the storage modulus of the hydrogel compared with the oxide starch crosslinked hydrogel.
SEM showed the OCS based hydrogels possess a well-defined porous structure. Furthermore,
doxorubicin (DOX) was used as model drug to investigate the control and release properties
of OCS hydrogels. This OCS hydrogel would be a promising drug carrier for biomedical
applications.