Updated estimate of AQP4-IgG serostatus and disability outcome in neuromyelitis optica.

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Abstract

To 1) determine, using contemporary recombinant antigen-based assays, the aquaporin-4 (AQP4)-immunoglobulin G (IgG) detection rate in sequential sera of patients assigned a clinical diagnosis of neuromyelitis optica (NMO) but initially scored negative by tissue-based indirect immunofluorescence (IIF) assay; and 2) evaluate the impact of serostatus on phenotype and outcome.

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Journal

Journal ID (iso-abbrev): Neurology

Title: Neurology

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1526-632X

ISSN (Print): 0028-3878

Publication date (Electronic): Oct 01 2013

Volume: 81

Issue: 14

Affiliations

[1 ] From the Departments of Laboratory Medicine and Pathology (Y.J., J.P.F., V.A.L., A.M.L.Q., A.M., R.I., S.J.P.), Neurology (V.A.L., A.M., C.C., B.G.W., C.F.L., S.J.P.), Immunology (V.A.L.), and Health Sciences Research (S.M.J., C.Y.S.), College of Medicine, Mayo Clinic, Rochester, MN; Department of Neurology (D.M.W.), College of Medicine, Mayo Clinic, Scottsdale, AZ; and Department of Neurology (E.A.S.), College of Medicine, Mayo Clinic, Jacksonville, FL.

Article

Publisher Item ID: WNL.0b013e3182a6cb5c

DOI: 10.1212/WNL.0b013e3182a6cb5c

PMC ID: 3795610

PubMed ID: 23997151

SO-VID: 7732ef58-14ed-4660-aa87-e06b95b2a107

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