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      Derivation of indoor air guidance values for volatile organic compounds (VOC) emitted from polyurethane flexible foam: VOC with repeated dose toxicity data

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          Abstract

          Polyurethane Flexible Foams (PUF) are versatile materials used in upholstered furniture and bed mattresses. Due to the production procedure, fresh foams emit volatile organic compounds (VOC). Chamber tests issued by the European association of flexible polyurethane foam blocks manufacturers (EUROPUR) revealed certain levels of VOCs, and the emission rates are declining over time. To assess the risk associated to these VOCs which, as a consequence, might be detectable in indoor air where these PUF are used. To evaluate the risk for consumers, their concentration can be matched against existing benchmarks for indoor air. These benchmarks are, for example, guidance values derived by the Advisory Group for Indoor Air Guidance Values of the German UBA (RW-values), Lowest Concentrations of Interest (LCI) for building products, or against derived no effect levels (DNELs) for consumers, defined in registration dossiers under the European Regulation No. 1907/2006. In this paper, indoor air guidance values are derived for some VOCs which do have neither RW- nor LCI-values, and no DNELs for consumers. Substances covered are trimethylsilanol, fluorotrimethylsilane, chloropropanol, propanal, triethylenediamine and 2,2,3,3-tetramethyl succinodinitrile.

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          A compilation of two decades of mutagenicity test results with the Ames Salmonella typhimurium and L5178Y mouse lymphoma cell mutation assays.

          As previously reported [Cameron, T. P., Rogers-Back, A. M., Lawlor, T. E., Harbell, J. W., Seifried, H. E., and Dunkel, V. C. (1991) Gentoxicity of multifunctional acrylates in the Salmonella/mammalian-microsome assay and mouse lymphoma TK+/- assay. Environ. Mol. Mutagen. 17, 264-271], the National Cancer Institute (NCI) shares the responsibility of selecting the most significant chemicals for carcinogenicity testing by the National Toxicology Program (NTP) and has used data from Salmonella and mouse lymphoma mutagenicity assays to aid in the selection and prioritization of chemicals to be further evaluated in chronic 2 year rodent studies. In addition, a number of antineoplastic and anti-AIDS drugs in preclinical evaluation were tested for the NCI's Division of Cancer Treatment Toxicology Branch. In the NCI/NTP chemical selection process, it is no longer necessary to test chemicals prior to sending them to the NTP so the NCI program has ceased performing mutagenicity tests. Some of the testing data has been made available in summary form in the Chemical Carcinogenisis Research Information System (CCRIS), which is searchable on the NLM TOXNET system. The limitations in using this source are that only summary results are available and many negative test results are not included. A summary table that presents the results for each compound is provided in the Appendix with raw data provided in the Supporting Information. The Appendix table contains the compound name, CAS number, and a summary of the data from the Ames test and the mouse lymphoma assay.
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            Richtwerte für die Innenraumluft: erste Fortschreibung des Basisschemas

            (2012)
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              Sensory irritation response to inhaled aldehydes after formaldehyde pretreatment.

              Pretreatment of Fischer-344 (F-344) rats with formaldehyde (HCHO) induces significant cross tolerance to the sensory irritation properties of Cl2. The purpose of this study was to determine if HCHO pretreatment would cause sensory irritation cross tolerance to other inhaled aldehydes. Male F-344 rats, weighing 190 to 210 g, were pretreated with 15 ppm HCHO, 6 hr/day for 9 days, and challenged on the 10th day with a saturated (acetaldehyde, propionaldehyde, and butyraldehyde), unsaturated (acrolein and crotonaldehyde), or cyclic (cyclohexanecarboxaldehyde, 3-cyclohexene-1-carboxaldehyde, and benzaldehyde) aldehyde. The sensory irritation response in these animals was quantified by measuring respiratory rate depression in a head-only inhalation chamber using plethysmographic techniques. Control animals were challenged identically without prior pretreatment. In naive (nonpretreated) animals, the concentration eliciting a 50% decrease in respiratory rate (RD50) was 23 ppm or less for unsaturated aliphatic aldehydes. For cyclic and saturated aliphatic aldehydes, the RD50 ranged from 600 to 1000 ppm and 3000 to 6800 ppm, respectively. Formaldehyde pretreatment resulted in cross tolerance only with acetaldehyde (RD50 increased 3.5-fold) and acrolein (RD50 increased 5-fold). These results indicate that the development of cross tolerance following HCHO pretreatment is not a general phenomenon. Prediction of acceptable concentrations of occupational exposure for the prevention of sensory irritation in humans has been based primarily on RD50 data for mice. Comparison of the RD50 values obtained for rats in this investigation with previously published results for mice varied by over one-half an order of magnitude, thereby disputing the usefulness of data from F-344 rats in setting threshold limit values for the prevention of sensory irritation.
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                Author and article information

                Journal
                EXCLI J
                EXCLI J
                EXCLI J
                EXCLI Journal
                Leibniz Research Centre for Working Environment and Human Factors
                1611-2156
                07 August 2018
                2018
                : 17
                : 784-791
                Affiliations
                [1 ]Muenster University of Applied Science, Chemical Engineering, Stegerwaldstrasse 39, D-48565 Steinfurt, GERMANY
                Author notes
                *To whom correspondence should be addressed: Thomas Schupp, Muenster University of Applied Science, Chemical Engineering, Stegerwaldstrasse 39, D-48565 Steinfurt, GERMANY; Tel.: +49 2551 962595, E-mail: thomas.schupp@ 123456fh-muenster.de
                Article
                2018-1440 Doc784
                10.17179/excli2018-1440
                6123614
                76c5dc69-292c-446a-ac8e-211df6bf8594
                Copyright © 2018 Schupp

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence ( http://creativecommons.org/licenses/by/4.0/) You are free to copy, distribute and transmit the work, provided the original author and source are credited.

                History
                : 18 June 2018
                : 02 August 2018
                Categories
                Original Article

                indoor air,guidance values,consumer exposure,risk,chamber test

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