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      Preparation and In Vitro Release of Total Alkaloids from Alstonia Scholaris Leaves Loaded mPEG-PLA Microspheres

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          Abstract

          Total alkaloids of Alstonia scholaris leaves (ASAs) are extracted from the lamp leaves, which have positive anti-inflammatory activity and remarkable effects in treating bronchitis. Due to its short half-life, we used a degradable mPEG-PLA to physically encapsulate the total alkali of the lamp stage, and prepared a sustained-release microsphere by double-emulsion method. The ASAs-loaded mPEG 10000-PLA microspheres were screened for better performance by testing the morphology, average particle size, embedding rate and drug loading of different molecular weight mPEG-PLA microspheres, which can stably and continuously release for 15 days at 37 °C. The results of cytotoxicity and blood compatibility indicated that the drug-loaded microspheres have beneficial biocompatibility. Animal experiments showed that the drug-loaded microspheres had a beneficial anti-inflammatory effect. These results all indicated that mPEG-PLA is a controlled release carrier material suitable for ASAs.

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          Biodegradation and biocompatibility of PLA and PLGA microspheres

          James M. Anderson, Matthew S Shive (2012)
          Article 0 comments Cited 163 times – based on 0 reviews     Review now
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            Evaluation of chitosan nano dressing for wound healing: characterization, in vitro and in vivo studies.

            D. Archana, Joydeep Dutta, P K Dutta (2013)
            In our present investigation, a ternary nano dressing consists of titanium dioxide nano particle loaded chitosan-pectin was prepared to evaluate biocompatibility, antimicrobial and in vivo wound healing properties. The photoactive property of TiO₂ based materials makes it important candidate for numerous medical applications. Chitosan can be easily processed into membranes, gels, nanofibers, beads, nanoparticles, scaffolds, and sponge forms that can be used in wound healing applications. Pectin acts as a natural prophylactic substance against poisoning with toxic cations and its styptic and curing effects are well documented in healing ointments. The characterizations of prepared nano dressing were made by FTIR, TGA, DSC, SEM and TEM. The physicochemical parameters of nano dressing were evaluated by various techniques, namely, the Whole blood clotting test, haemolysis ratio measurement, cytotoxicity test using NIH3T3 and L929 fibroblast cells. The in vivo open excision-type wound healing efficiency of prepared nano dressing and its comparison with conventional gauze were evaluated by measuring wound contraction and histological examinations in adult male albino rats. The synergistic effects of nano dressing such as good antibacterial ability, high swelling properties, high water vapour transmission rate (WVTR), excellent hydrophilic nature, biocompatibility, wound appearance, wound closure rate and histological study through in vivo test makes it a suitable candidate for wound healing applications.
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              Chitosan/gelatin composite sponge is an absorbable surgical hemostatic agent.

              Guangqian Lan, Bitao Lu, Tianyou Wang … (2015)
              Chitosan is a versatile biological material that is very well known for its hemostatic properties. The purpose of this study was to test the hemostatic properties of a chitosan composite obtained from silkworm pupae and gelatin. This spongy porous material was cross-linked with tannins and then freeze-dried under vacuum to obtain composites containing chitosan and gelatin in different proportions. Results showed that the best blood-clotting index (BCI) was achieved in vitro by a chitosan/gelatin sponge (CG) ratio of 5/5 (W/W). Furthermore, CG had the best hemostatic effect in rabbit artery bleeding and liver model tests compared to the two components separately. The better hemostatic effect of CG may be due to its ability to absorb blood platelets easily and to the higher liquid adsorption ratio. However, no obvious differences were observed in thrombin generation with both aPTT and PT tests. Cell toxicity tests with L929 cells showed that CG caused no obvious cytotoxicity. In addition, subcutaneous transplantation of CG into rabbits resulted in almost complete degradation of CG after 6 weeks, together with rich vascular generation and proliferation in the transplanted region. Thus, CG can be considered an effective absorbable hemostatic material.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Materials (Basel)
                Journal ID (iso-abbrev): Materials (Basel)
                Journal ID (publisher-id): materials
                Title: Materials
                Publisher: MDPI
                ISSN (Electronic): 1996-1944
                Publication date (Electronic): 06 May 2019
                Publication date Collection: May 2019
                Volume: 12
                Issue: 9
                Electronic Location Identifier: 1457
                Affiliations
                [1 ]National and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials, Yunnan Minzu University, Kunming 650500, China; zhengxiangyu1993@ 123456163.com (X.Z.); honglili@ 123456vip.163.com (H.L.); heyi_sichuan@ 123456163.com (Y.H.); yuanmingwei@ 123456163.com (M.Y.); yangrenyu1995@ 123456163.com (R.Y.); jnf1514@ 123456163.com (N.J.)
                [2 ]National and Local Joint Engineering Laboratory for Synthesis Technology of High Performance Polymer, Jilin University, Changchun 130012, China; sml199211@ 123456163.com
                Author notes
                [* ]Correspondence: yml@ 123456188.com (M.Y.); yangcui@ 123456ynni.edu.cn (C.Y.); Tel.: +86-871-6591-4825 (M.Y. & C.Y.)
                Author information
                https://orcid.org/0000-0003-2899-9584
                Article
                Publisher ID: materials-12-01457
                DOI: 10.3390/ma12091457
                PMC ID: 6540593
                PubMed ID: 31064081
                SO-VID: 75da6d1c-40ed-4ef0-87c2-4a2c1772ca22
                Copyright © © 2019 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 03 April 2019
                Date accepted : 28 April 2019
                Categories
                Subject: Article

                Keywords: total alkaloids from alstonia scholaris leaves,mpeg-pla,microspheres,drug release,biocompatibility
                Data availability:
                Keywords: total alkaloids from alstonia scholaris leaves, mpeg-pla, microspheres, drug release, biocompatibility

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