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      The safety and feasibility of laparoscopic redo surgery for recurrent Crohn’s disease: A comparative clinical study of over 100 consecutive patients

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          Abstract

          Background

          Despite advances in medical treatments, most patients with Crohn's disease (CD) will still require surgery, with 20%‐50% needing redo surgery within 10 years after the primary procedure. There is no consensus on the application of laparoscopic redo surgery for recurrent CD.

          Methods

          This study included 107 patients with CD who underwent surgery from 2012 to 2020 at Osaka University Hospital. All procedures were laparoscopic. Patients were grouped based on whether the surgery was redo or primary for evaluation of the safety and feasibility of laparoscopic redo surgery.

          Results

          The study included 40 patients undergoing redo surgery and 67 having primary surgery. The median age at the time of the procedure was higher for those undergoing redo surgery (43 years vs 34 years, P < 0.0031), as were the duration of CD (16.5 years vs 8.3 years, P < 0.0012) and number of operating minutes (231.0 min vs 169.0 min, P < 0.0001). The remnant bowel length was shorter in the redo surgery group (270.0 cm vs 410.0 cm, P < 0.0001). Rates of open conversion were comparable between the two groups (10.0% vs 3.0%, P = 0.127), as were postoperative complications (32.5% vs 20.9%, P = 0.1812).

          Conclusions

          These results suggest that laparoscopic redo surgery is safe and feasible, with comparable conversion rates and postoperative complications in experienced institutions.

          Abstract

          There is no consensus on the application of redo surgery for recurrent CD. Here, we evaluated the safety and feasibility of laparoscopic redo surgery.

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          Most cited references29

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          A comparison of laparoscopically assisted and open colectomy for colon cancer.

          Minimally invasive, laparoscopically assisted surgery was first considered in 1990 for patients undergoing colectomy for cancer. Concern that this approach would compromise survival by failing to achieve a proper oncologic resection or adequate staging or by altering patterns of recurrence (based on frequent reports of tumor recurrences within surgical wounds) prompted a controlled trial evaluation. We conducted a noninferiority trial at 48 institutions and randomly assigned 872 patients with adenocarcinoma of the colon to undergo open or laparoscopically assisted colectomy performed by credentialed surgeons. The median follow-up was 4.4 years. The primary end point was the time to tumor recurrence. At three years, the rates of recurrence were similar in the two groups--16 percent among patients in the group that underwent laparoscopically assisted surgery and 18 percent among patients in the open-colectomy group (two-sided P=0.32; hazard ratio for recurrence, 0.86; 95 percent confidence interval, 0.63 to 1.17). Recurrence rates in surgical wounds were less than 1 percent in both groups (P=0.50). The overall survival rate at three years was also very similar in the two groups (86 percent in the laparoscopic-surgery group and 85 percent in the open-colectomy group; P=0.51; hazard ratio for death in the laparoscopic-surgery group, 0.91; 95 percent confidence interval, 0.68 to 1.21), with no significant difference between groups in the time to recurrence or overall survival for patients with any stage of cancer. Perioperative recovery was faster in the laparoscopic-surgery group than in the open-colectomy group, as reflected by a shorter median hospital stay (five days vs. six days, P<0.001) and briefer use of parenteral narcotics (three days vs. four days, P<0.001) and oral analgesics (one day vs. two days, P=0.02). The rates of intraoperative complications, 30-day postoperative mortality, complications at discharge and 60 days, hospital readmission, and reoperation were very similar between groups. In this multi-institutional study, the rates of recurrent cancer were similar after laparoscopically assisted colectomy and open colectomy, suggesting that the laparoscopic approach is an acceptable alternative to open surgery for colon cancer. Copyright 2004 Massachusetts Medical Society
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            Risk factors for surgery and recurrence in 907 patients with primary ileocaecal Crohn's disease.

            Previous studies on risk factors for resection and postoperative recurrence in Crohn's disease have given inconclusive results. The aim of this study was to assess the risk for resection and postoperative recurrence in the treatment of ileocaecal Crohn's disease and to define factors affecting the course of the disease. A population-based cohort of 907 patients with primary ileocaecal Crohn's disease was reviewed retrospectively. Resection rates were 61, 77 and 83 per cent at 1, 5 and 10 years respectively after the diagnosis. Relapse rates were 28 and 36 per cent 5 and 10 years after the first resection. A younger age at diagnosis resulted in a low resection rate. The presence of perianal Crohn's disease and long resection segments increased the incidence of recurrence, and resection for a palpable mass and/or abscess decreased the recurrence rate. A decrease in recurrence rate during the study period (1955-1989) was observed. In ileocaecal Crohn's disease the probability of resection is high and the risk of recurrence moderate. Crohn's disease in childhood carries a lower risk of primary resection. Perianal disease and extensive ileal resection increase the risk of recurrence.
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              • Article: not found

              Risk factors for postoperative intra-abdominal septic complications after surgery in Crohn's disease: A meta-analysis of observational studies.

              Postoperative intra-abdominal septic complications [IASCs] are the most feared risks of surgery for Crohn's disease[CD]. The risk factors for IASCs still remain controversial. The aim of this study was to assess the risk factors for IASCs in CD patients undergoing abdominal surgery.
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                Author and article information

                Contributors
                togino04@gesurg.med.osaka-u.ac.jp
                Journal
                Ann Gastroenterol Surg
                Ann Gastroenterol Surg
                10.1002/(ISSN)2475-0328
                AGS3
                Annals of Gastroenterological Surgery
                John Wiley and Sons Inc. (Hoboken )
                2475-0328
                16 December 2021
                May 2022
                : 6
                : 3 ( doiID: 10.1002/ags3.v6.3 )
                : 405-411
                Affiliations
                [ 1 ] Department of Gastroenterological Surgery Osaka University Graduate School of Medicine Suita Japan
                [ 2 ] Department of Therapeutics for Inflammatory Bowel Diseases Osaka University Graduate School of Medicine Suita Japan
                Author notes
                [*] [* ] Correspondence

                Takayuki Ogino, Department of Gastroenterological Surgery, Department of Therapeutics for Inflammatory Bowel Diseases, Osaka University, 2‐2‐E2 Yamadaoka, Suita, Osaka, 565‐0871, Japan.

                Email: togino04@ 123456gesurg.med.osaka-u.ac.jp

                Author information
                https://orcid.org/0000-0001-5435-4144
                https://orcid.org/0000-0003-1113-8884
                https://orcid.org/0000-0002-2318-1129
                https://orcid.org/0000-0002-0825-6823
                Article
                AGS312534
                10.1002/ags3.12534
                9130919
                35634187
                75cee919-5015-441e-a482-73127989c63e
                © 2021 The Authors. Annals of Gastroenterological Surgery published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Gastroenterology.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 05 November 2021
                : 20 August 2021
                : 29 November 2021
                Page count
                Figures: 2, Tables: 3, Pages: 7, Words: 4933
                Categories
                Original Article
                Original Articles
                Custom metadata
                2.0
                May 2022
                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.1.6 mode:remove_FC converted:25.05.2022

                adhesion,crohn's disease,laparoscopic surgery,redo surgery

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