Ying-Qiu Zheng:
ORCID: http://orcid.org/0000-0003-1236-0700
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: SoftwareRole: ValidationRole: VisualizationRole: Writing – original
draftRole: Writing – review & editing
Yu Zhang:
ORCID: http://orcid.org/0000-0001-7159-4561
Role: ConceptualizationRole: MethodologyRole: Software
Yvonne Yau:
ORCID: http://orcid.org/0000-0002-6095-7205
Role: MethodologyRole: Writing – review & editing
Yashar Zeighami:
ORCID: http://orcid.org/0000-0002-0583-5811
Role: Formal analysisRole: MethodologyRole: Software
Kevin Larcher: Role: MethodologyRole: Software
Bratislav Misic:
ORCID: http://orcid.org/0000-0003-0307-2862
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: SupervisionRole: ValidationRole: VisualizationRole: Writing – original
draftRole: Writing – review & editing
Alain Dagher:
ORCID: http://orcid.org/0000-0002-0945-5779
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole:
Writing – original draftRole: Writing – review & editing
Henry Kennedy: Role: Academic Editor
Journal ID (nlm-ta): PLoS Biol
Journal ID (iso-abbrev): PLoS Biol
Journal ID (publisher-id): plos
Journal ID (pmc): plosbiol
Title:
PLoS Biology
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1544-9173
ISSN
(Electronic):
1545-7885
Publication date
(Electronic):
21
November
2019
Publication date Collection:
November
2019
Publication date PMC-release: 21
November
2019
Volume: 17
Issue: 11
Electronic Location Identifier: e3000495
Affiliations
[1
]
McConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University,
Montréal, Quebec, Canada
[2
]
Centre de Recherche de I'Institut Universitaire de Gériatrie de Montréal, Montréal,
Canada
Author notes
The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PBIOLOGY-D-19-02034
DOI: 10.1371/journal.pbio.3000495
PMC ID: 6894889
PubMed ID: 31751329
SO-VID: 7552e301-b0c5-4a9f-a2a3-ab7e22aca1e5
Copyright © © 2019 Zheng et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/501100000024, Canadian Institutes of Health Research;
Award ID: FDN-143242
Award Recipient
:
ORCID: http://orcid.org/0000-0002-0945-5779
Alain Dagher
Funded by: funder-id http://dx.doi.org/10.13039/100000864, Michael J. Fox Foundation for Parkinson's Research;
Award ID: Biomarkers Across Neurodegenerative Diseases
Award Recipient
:
ORCID: http://orcid.org/0000-0002-0945-5779
Alain Dagher
Funded by: funder-id http://dx.doi.org/10.13039/100000957, Alzheimer's Association;
Award ID: Biomarkers Across Neurodegenerative Diseases
Award Recipient
:
ORCID: http://orcid.org/0000-0002-0945-5779
Alain Dagher
Funded by: funder-id http://dx.doi.org/10.13039/100012479, Weston Brain Institute;
Award ID: Biomarkers Across Neurodegenerative Diseases
Award Recipient
:
ORCID: http://orcid.org/0000-0002-0945-5779
Alain Dagher
Funded by: funder-id http://dx.doi.org/10.13039/501100010785, Canada First Research Excellence Fund;
Award ID: Healthy Brain for Healthy Lives
Award Recipient
:
ORCID: http://orcid.org/0000-0002-0945-5779
Alain Dagher
Funded by: funder-id http://dx.doi.org/10.13039/501100000038, Natural Sciences and Engineering Research Council of Canada;
Award ID: RGPIN #017-04265
Award Recipient
:
ORCID: http://orcid.org/0000-0003-0307-2862
Bratislav Misic
Funded by: funder-id http://dx.doi.org/10.13039/501100000156, Fonds de Recherche du Québec - Santé;
Award ID: Chercheur Boursier
Award Recipient
:
ORCID: http://orcid.org/0000-0003-0307-2862
Bratislav Misic
This research was undertaken thanks in part to funding from the Canada First Research
Excellence Fund, awarded to McGill University for the Healthy Brains for Healthy Lives
initiative. AD received funding from the Canadian Institutes for Health Research (grant
number FDN-143242), Natural Sciences and Engineering Research Council of Canada, Michael
J. Fox Foundation, Weston Brain Institute, and the Alzheimer Association. BM acknowledges
support from the Natural Sciences and Engineering Research Council of Canada (NSERC
Discovery Grant RGPIN 017-04265), the Fonds de recherche Qu ébec–Sant é (Chercheur
Boursier), and the Canadian Institutes of Health Research (CIHR; Project Grant 391300).
PPMI—a public-private partnership—is funded by the Michael J. Fox Foundation for Parkinson’s
Research and funding partners, including AbbVie, Avid, Biogen, Bristol-Myers Squibb,
Covance, GE Healthcare, Genentech, GlaxoSmithKline, Lilly, Lundbeck, Merck, Meso Scale
Discovery, Pfizer, Piramal, Roche, Sanofi Genzyme, Servier, Teva, and UCB. The funders
had no role in study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Signs and Symptoms
Subject:
Atrophy
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Signs and Symptoms
Subject:
Atrophy
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Gene Expression
Subject:
Research and Analysis Methods
Subject:
Simulation and Modeling
Subject:
Agent-Based Modeling
Subject:
Computer and Information Sciences
Subject:
Systems Science
Subject:
Agent-Based Modeling
Subject:
Physical Sciences
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Mathematics
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Systems Science
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Agent-Based Modeling
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Medicine and Health Sciences
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Neurology
Subject:
Neurodegenerative Diseases
Subject:
Movement Disorders
Subject:
Parkinson Disease
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Brain
Subject:
Substantia Nigra
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Brain
Subject:
Substantia Nigra
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Brain Mapping
Subject:
Connectomics
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Nervous System
Subject:
Neuroanatomy
Subject:
Connectomics
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Medicine and Health Sciences
Subject:
Anatomy
Subject:
Nervous System
Subject:
Neuroanatomy
Subject:
Connectomics
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Neuroanatomy
Subject:
Connectomics
Subject:
Medicine and Health Sciences
Subject:
Epidemiology
Subject:
Infectious Disease Epidemiology
Subject:
Medicine and Health Sciences
Subject:
Infectious Diseases
Subject:
Infectious Disease Epidemiology
Subject:
Medicine and Health Sciences
Subject:
Neurology
Subject:
Neurodegenerative Diseases