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      Long non-coding RNAs in hematopoietic regulation

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          Abstract

          Long non-coding RNAs (lncRNAs) have crucial roles via tethering with DNA, RNA or protein in diverse biological processes. These lncRNA-mediated interactions enhance gene regulatory networks and modulate a wide range of downstream genes. It has been demonstrated that several lncRNAs act as key regulators in hematopoiesis. This review highlights the roles of lncRNAs in normal hematopoietic development and discusses how lncRNA dysregulation correlates with disease prognoses and phenotypes.

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          Gene regulation in the immune system by long noncoding RNAs

          Ansuman Satpathy, Y. Chen, Howard Y. Chang (2017)
          Long non-coding RNAs (lncRNAs) are being increasingly appreciated as important regulators of gene expression. Chang and colleagues review the roles identified for lncRNAs in the immune system and discuss models for how lncRNAs mediate their effects.
          Article 0 comments Cited 352 times – based on 0 reviews     Review now
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            Accumulation of miR-155 and BIC RNA in human B cell lymphomas.

            Peggy Eis, Wayne Tam, Liping Sun … (2005)
            We show that the microRNA miR-155 can be processed from sequences present in BIC RNA, a spliced and polyadenylated but non-protein-coding RNA that accumulates in lymphoma cells. The precursor of miR-155 is likely a transient spliced or unspliced nuclear BIC transcript rather than accumulated BIC RNA, which is primarily cytoplasmic. By using a sensitive and quantitative assay, we find that clinical isolates of several types of B cell lymphomas, including diffuse large B cell lymphoma (DLBCL), have 10- to 30-fold higher copy numbers of miR-155 than do normal circulating B cells. Similarly, the quantities of BIC RNA are elevated in lymphoma cells, but ratios of the amounts of the two RNAs are not constant, suggesting that the level of miR-155 is controlled by transcription and processing. Significantly higher levels of miR-155 are present in DLBCLs with an activated B cell phenotype than with the germinal center phenotype. Because patients with activated B cell-type DLBCL have a poorer clinical prognosis, quantification of this microRNA may be diagnostically useful.
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              Long noncoding RNAs in cell-fate programming and reprogramming.

              Ryan Flynn, Howard Y. Chang (2014)
              In recent years, long noncoding RNAs (lncRNAs) have emerged as an important class of regulators of gene expression. lncRNAs exhibit several distinctive features that confer unique regulatory functions, including exquisite cell- and tissue-specific expression and the capacity to transduce higher-order spatial information. Here we review evidence showing that lncRNAs exert critical functions in adult tissue stem cells, including skin, brain, and muscle, as well as in developmental patterning and pluripotency. We highlight new approaches for ascribing lncRNA functions and discuss mammalian dosage compensation as a classic example of an lncRNA network coupled to stem cell differentiation.
              Article 0 comments Cited 269 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Fang Wang
                Jia Yu
                Journal
                Journal ID (nlm-ta): Cell Regen (Lond)
                Journal ID (iso-abbrev): Cell Regen (Lond)
                Title: Cell Regeneration
                Publisher: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
                ISSN (Electronic): 2045-9769
                Publication date PMC-release: 11 October 2018
                Publication date Collection: December 2018
                Publication date (Electronic): 11 October 2018
                Volume: 7
                Issue: 2
                Pages: 27-32
                Affiliations
                [a ]State Key Laboratory of Medical Molecular Biology, Department of Biochemistry & Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College (PUMC), Beijing, 100005, China
                [b ]Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences, Beijing, 100730, China
                Author notes
                [∗ ]Corresponding author. State Key Laboratory of Medical Molecular Biology, Department of Biochemistry & Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College (PUMC), Beijing, 100005, China. j-yu@ 123456ibms.pumc.edu.cn
                [∗∗ ]Corresponding author. State Key Laboratory of Medical Molecular Biology, Department of Biochemistry & Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College (PUMC), Beijing, 100005, China. wo_wfang@ 123456hotmail.com
                Article
                Publisher ID: S2045-9769(18)30006-3
                DOI: 10.1016/j.cr.2018.08.001
                PMC ID: 6326246
                SO-VID: 74d530bf-e701-4632-b8ed-6efe2aaadf13
                Copyright © © 2018 Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences. Production and hosting by Elsevier B.V. on behalf of KeAi.
                License:

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                Date received : 7 July 2018
                Date revision received : 11 August 2018
                Date accepted : 21 August 2018
                Categories
                Subject: Article

                Keywords: lncrnas,hematopoiesis,leukemia
                Data availability:
                Keywords: lncrnas, hematopoiesis, leukemia

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