Nutrient-induced stimulation of protein synthesis in mouse skeletal muscle is limited by the mTORC1 repressor REDD1.

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Abstract

In skeletal muscle, the nutrient-induced stimulation of protein synthesis requires signaling through the mechanistic target of rapamycin complex 1 (mTORC1). Expression of the repressor of mTORC1 signaling, regulated in development and DNA damage 1 (REDD1), is elevated in muscle during various atrophic conditions and diminished under hypertrophic conditions. The question arises as to what extent REDD1 limits the nutrient-induced stimulation of protein synthesis.

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Author and article information

Journal

Journal ID (iso-abbrev): J. Nutr.

Title: The Journal of nutrition

ISSN (Electronic): 1541-6100

ISSN (Print): 0022-3166

Publication date (Electronic): Apr 2015

Volume: 145

Issue: 4

Affiliations

[1 ] Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA; and.

[2 ] Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, NY.

[3 ] Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA; and skimball@psu.edu.

Article

Publisher Item ID: jn.114.207621

DOI: 10.3945/jn.114.207621

PubMed ID: 25716553

SO-VID: 73a63224-cfc0-49ef-b20d-2cad76d00054

History

Keywords: 70-kDa ribosomal protein S6 kinase,DDIT4,atrophy,eukaryotic initiation factor 4E binding protein 1,hypertrophy,mammalian target of rapamycin,refeeding

Data availability:

Keywords: 70-kDa ribosomal protein S6 kinase, DDIT4, atrophy, eukaryotic initiation factor 4E binding protein 1, hypertrophy, mammalian target of rapamycin, refeeding

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