A Universal Soaking Strategy to Convert Composite Hydrogels into Extremely Tough and Rapidly Recoverable Double-Network Hydrogels

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Abstract

Soak n' Boost: A universal strategy to manufacture hybrid double-network hydrogels with eminent mechanical properties is developed by postformation of the chitosan microcrystalline and chain-entanglement physical networks via simple treatment of the chitosan composite hydrogels using alkaline and saline solutions. The strategy may open an avenue to fabricate multifarious double-network hydrogels for promising applications in antifouling materials, drug delivery, and tissue engineering.

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A Mechanically Strong, Highly Stable, Thermoplastic, and Self-Healable Supramolecular Polymer Hydrogel

Wei Min Wang, Tao Bai, Lina Gao … (2015)

Polymerization of glycinamide-conjugated monomer alone in concentrated aqueous solution enables facile formation of a mechanically strong and a highly stable supramolecular polymer (SP) hydrogel because of the cooperatively hydrogen-bonded crosslinking and strengthening effect from dual amide motifs. This SP hydrogel exhibits thermoplastic processability, injectability, and self-reparability because of the dynamic destruction and reconstruction of hydrogen bonds in response to temperature change.

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Adaptable hydrogel networks with reversible linkages for tissue engineering.

Huiyuan Wang, Sarah Heilshorn (2015)

Adaptable hydrogels have recently emerged as a promising platform for three-dimensional (3D) cell encapsulation and culture. In conventional, covalently crosslinked hydrogels, degradation is typically required to allow complex cellular functions to occur, leading to bulk material degradation. In contrast, adaptable hydrogels are formed by reversible crosslinks. Through breaking and re-formation of the reversible linkages, adaptable hydrogels can be locally modified to permit complex cellular functions while maintaining their long-term integrity. In addition, these adaptable materials can have biomimetic viscoelastic properties that make them well suited for several biotechnology and medical applications. In this review, an overview of adaptable-hydrogel design considerations and linkage selections is presented, with a focus on various cell-compatible crosslinking mechanisms that can be exploited to form adaptable hydrogels for tissue engineering.