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      Morpholinyl silicon phthalocyanine nanoparticles with lysosome cell death and two-photon imaging functions for in vitro photodynamic therapy of cancer cells

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          Abstract

          The lysosome is an important target for realizing antitumor therapy. Lysosomal cell death exerts significant therapeutic effects on apoptosis and drug-resistance. The development of lysosome-targeting nanoparticles to obtain efficient cancer treatment is challenging. In this article, nanoparticles composed of DSPE@M-SiPc and possessing bright two-photon fluorescence, lysosome targeting ability, and photodynamic therapy multifunctionalities are prepared by encapsulating morpholinyl-substituted silicon phthalocyanine (M-SiPc) with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(poly(ethylene glycol))-2000] (DSPE). Two photon fluorescence bioimaging showed that M-SiPc and DSPE@M-SiPc mainly locate in lysosomes after cellular internalization. Upon irradiation, DSPE@M-SiPc effectively generates reactive oxygen species and damages the function of lysosome, subsequently leading to lysosomal cell death. DSPE@M-SiPc is a promising photosensitizer for cancer treatment.

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          Cell Death Mediated by the Pyroptosis Pathway with the Aid of Nanotechnology: Prospects for Cancer Therapy

          Dan Wu, Sheng WANG, Guocan Yu … (2021)
          Pyroptosis, a unique form of programmed cell death (PCD) that is characterized by DNA fragmentation, chromatin condensation, cellular swelling with big bubbles, and leakage of cell content, has been proven to have a close relationship with human diseases, such as inflammatory diseases and malignant tumors. Since a new gasdermin-D (GSDMD) protein was identified in 2015, various strategies have been developed to induce pyroptosis for cancer therapy, including ions, small-molecule drugs and nanomaterials. Although there are a number of reviews about the close relationship between the pyroptosis mechanism and the occurrence of various cancers, a summary covering recent progress in the field of nanomedicines in pyroptosis-based cancer therapy has not yet been presented. Therefore, it is urgent to fill this gap and light up future directions for the use of this powerful tool to combat cancer. In this Minireview, recent progress in cancer treatment based on pyroptosis induced by nanoparticles will be described in detail, the design highlights and the therapeutic advantages are emphasized, and future perspectives in this emerging area are proposed.
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            Effects of substituents on the photochemical and photophysical properties of main group metal phthalocyanines

            Tebello Nyokong (2007)
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              Improving Image‐Guided Surgical and Immunological Tumor Treatment Efficacy by Photothermal and Photodynamic Therapies Based on a Multifunctional NIR AIEgen

              Ruming Jiang, Jun Dai, Xiaoqi Dong … (2021)
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                Author and article information

                Contributors
                Journal
                Journal ID (nlm-ta): Front Bioeng Biotechnol
                Journal ID (iso-abbrev): Front Bioeng Biotechnol
                Journal ID (publisher-id): Front. Bioeng. Biotechnol.
                Title: Frontiers in Bioengineering and Biotechnology
                Publisher: Frontiers Media S.A.
                ISSN (Electronic): 2296-4185
                Publication date (Electronic): 05 May 2023
                Publication date Collection: 2023
                Volume: 11
                Electronic Location Identifier: 1181448
                Affiliations
                [1] 1 College of Chemistry and Chemical Engineering , Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering , Fujian Province Key Laboratory of Polymer Materials , Fujian Normal University , Fuzhou, China
                [2] 2 College of Photonic & Electronic Engineering , Fujian Normal University , Fuzhou, China
                [3] 3 Department of Pathology , The First Affiliated Hospital of Fujian Medical University , Fuzhou, Fujian, China
                Author notes

                Edited by: Mohamed El-Aassar, Jouf University, Saudi Arabia

                Reviewed by: Fozia Rehman, COMSATS University Islamabad, Lahore Campus, Pakistan

                Dan Wu, Zhejiang University of Technology, China

                *Correspondence: Yiru Peng, yirupeng@ 123456fjnu.edu.cn ; Linying Chen, chenly2006@ 123456126.com
                [ † ]

                These authors have contributed equally to this work

                Article
                Publisher ID: 1181448
                DOI: 10.3389/fbioe.2023.1181448
                PMC ID: 10196173
                SO-VID: 708f1a8e-ac9c-4faa-bd4d-5baeb8e5472d
                Copyright © Copyright © 2023 Yu, Chen, Chen, Zhang, Li, Chen, Peng and Chen.
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                Date received : 07 March 2023
                Date accepted : 24 April 2023
                Funding
                This research was funded by the National Natural Science Foundation of China (21274021), the Natural Science Foundation of Fujian (2019Y0007, 2020J011202), the Joint Funds of Fujian Provincial Health and Education Research (2019-WJ-23), and the Joint Funds for the Innovation of Science and Technology, Fujian Province (2021Y9145).
                Categories
                Subject: Bioengineering and Biotechnology
                Subject: Original Research
                Custom metadata
                section-at-acceptance Biomaterials

                Keywords: morpholine,phthalocyanine,lysosome target,two-photon bio-imaging,photodynamic therapy
                Data availability:
                Keywords: morpholine, phthalocyanine, lysosome target, two-photon bio-imaging, photodynamic therapy

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