Direct hydrogen peroxide (H 2O 2) electrosynthesis via the two-electron oxygen reduction reaction is a sustainable alternative to the traditional energy-intensive anthraquinone technology. However, high-performance and scalable electrocatalysts with industrial-relevant production rates remain to be challenging, partially due to insufficient atomic level understanding in catalyst design. Here we utilize theoretical approaches to identify transition-metal single-site catalysts for two-electron oxygen reduction using the *OOH binding energy as a descriptor. The theoretical predictions are then used as guidance to synthesize the desired cobalt single-site catalyst with a O-modified Co-(pyrrolic N) 4 configuration that can achieve industrial-relevant current densities up to 300 mA cm − 2 with 96–100% Faradaic efficiencies for H 2O 2 production at a record rate of 11,527 mmol h − 1 g cat − 1. Here, we show the feasibility and versatility of metal single-site catalyst design using various commercial carbon and cobalt phthalocyanine as starting materials and the high applicability for H 2O 2 electrosynthesis in acidic, neutral and alkaline electrolytes.
Direct hydrogen peroxide electrosynthesis offers a sustainable alternative to the traditional energy-intensive anthraquinone technology. Here, the authors report a scalable cobalt single-site catalyst for hydrogen peroxide synthesis at industrial-relevant currents in acidic, neutral or alkaline electrolyte.