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Intra-arrest transnasal evaporative cooling: a randomized, prehospital, multicenter study (PRINCE: Pre-ROSC IntraNasal Cooling Effectiveness).

Author(s): Henrik Nordberg, Christian Storm, Hans-Jörg Busch, F Eichwede, Didier Desruelles, Fabio Taccone, Harald Fritz, Michel Vergnion, Jean-Louis Vincent, Fabien Guérisse, Pierre Mols, Leif Svensson, Tilmann Schwab, D Barbut, P Durnez, Maaret Castrén, Antonio Pesenti, Markus Roeßler, Jan Pachl, Thomas Elste, B Inderbitzen

Publication date: 2010-08-17

Journal: Circulation

Keywords: Administration, Intranasal, Aged, Body Temperature, physiology, Cold Temperature, Emergency Medical Services, methods, Female, Heart Arrest, physiopathology, therapy, Humans, Hypothermia, Induced, instrumentation, Male, Middle Aged, Prospective Studies, Time Factors

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Abstract

Transnasal evaporative cooling has sufficient heat transfer capacity for effective intra-arrest cooling and improves survival in swine. The aim of this study was to determine the safety, feasibility, and cooling efficacy of prehospital transnasal cooling in humans and to explore its effects on neurologically intact survival to hospital discharge. Witnessed cardiac arrest patients with a treatment interval