Cigarette Smoking Condensate Disrupts Endoplasmic Reticulum-Golgi Network Homeostasis Through GOLPH3 Expression in Normal Lung Epithelial Cells.

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Abstract

Cigarette smoke (CS) is associated with a broad range of diseases including lung cancer. Many researchers have suggested that cigarette smoke condensate (CSC) may be more toxic compared to cigarette smoke extract (CSE) because CSC contains the lipid-soluble faction of smoke while CSE contains the hydrophilic or gas phase. The aim of this research is to investigate the effects of CSC on the disruption of endoplasmic reticulum (ER)-Golgi homeostasis in normal lung epithelial cells.

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Journal

Journal ID (iso-abbrev): Nicotine Tob. Res.

Title: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1469-994X

ISSN (Print): 1462-2203

Publication date (Electronic): September 2016

Volume: 18

Issue: 9

Affiliations

[1 ] Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, Korea.

[2 ] Department of Chemical and Biomedical Engineering, Cleveland State University, Cleveland, OH.

[3 ] Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University , Seoul , Korea.

[4 ] Graduate Group of Tumor Biology, Seoul National University, Seoul, Korea.

[5 ] Inhalation Toxicology Research Center, Korea Institute of Toxicology, Jeongeup, Korea.

[6 ] Human and Environment Toxicology, University of Science and Technology, Daejeon, Korea.

[7 ] Department of Food Science and Technology, Sejong University , Seoul , Korea.

[8 ] Graduate School of Convergence Science and Technology, Seoul National University, Suwon, Korea.

[9 ] Advanced Institute of Convergence Technology, Seoul National University, Suwon, Korea.

[10 ] Institute of GreenBio Science Technology, Seoul National University, Pyeongchang-gun, Korea.

Article

Publisher Item ID: ntw079

DOI: 10.1093/ntr/ntw079

PubMed ID: 27611309

SO-VID: 6ad2ecaf-f524-4e28-9105-38bb77206724

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