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      Gain and loss of T cell subsets in old age--age-related reshaping of the T cell repertoire.

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          Abstract

          The immune system is affected by the aging process and undergoes significant age-related changes, termed immunosenescence. Different T cell subsets are affected by this process. Alterations within the bone marrow and thymus lead to a shift in the composition of the T cell repertoire from naïve to antigen-experienced T cells, thereby compromising the diversity of the T cell pool. Additional infection with latent pathogens such as cytomegalovirus aggravates this process. In this review, we focus on the major age-related changes that occur in the naïve and the antigen-experienced T cell population. We discuss the mechanisms responsible for the generation and maintenance of these subsets and how age-related changes can be delayed or prevented by clinical interventions.

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          Author and article information

          Journal
          J Clin Immunol
          Journal of clinical immunology
          Springer Science and Business Media LLC
          1573-2592
          0271-9142
          Apr 2011
          : 31
          : 2
          Affiliations
          [1 ] Immunology Division, Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria.
          Article
          10.1007/s10875-010-9499-x
          21243520
          698f74e5-c9d8-4ca8-b6aa-71c30ff2d264
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