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      Intraocular lens power calculation in keratoconus; A review of literature

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          Abstract

          Purpose

          To review the published literature regarding cataract surgery in keratoconus (KCN) patients with emphasis on challenges encountered during intraocular lens (IOL) power calculation and their solutions.

          Methods

          A literature review was performed to investigate all the relevant articles on the advancements of IOL calculations in KCN patients.

          Results

          Cataract surgery in keratoconic eyes can improve patients' refraction, and proper patient selection and IOL calculation methods are necessary to get the best results. The main problem in KCN patients is unreliable biometric measurements. It is more difficult to make conclusions in more advanced keratoconic corneas, as the steep keratometric values in these eyes will result in the selection of a low-power IOL. Presence of a low-power IOL will yield in extreme postoperative hyperopia, and IOL exchange might be mandatory. In cases in which keratoplasty may be needed in the future, contact lens fitting can help surgeons make a better decision preoperatively. Axial length (AL) measurements may have better repeatability and reproducibility than keratometry (K) readings in keratoconic eyes. SRK II formula may provide the most accurate IOL power in mild KCN. There is still not a comprehensive consensus of which formula is the best one in moderate and severe KCN, as the literature is limited in this subject.

          Conclusions

          Various methods of IOL power calculation optimization and recommendations may hold the key to improve surgical outcomes in keratoconic eyes. There are multiple sources of biometric error in KCN patients, hence IOL calculation methods may not be as efficient as expected in these eyes.

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          Most cited references43

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          Comparison of immersion ultrasound biometry and partial coherence interferometry for intraocular lens calculation according to Haigis.

          The precision of intraocular lens (IOL) calculation is essentially determined by the accuracy of the measurement of axial length. In addition to classical ultrasound biometry, partial coherence interferometry serves as a new optical method for axial length determination. A functional prototype from Carl Zeiss Jena implementing this principle was compared with immersion ultrasound biometry in our laboratory. In 108 patients attending the biometry laboratory for planning of cataract surgery, axial lengths were additionally measured optically. Whereas surgical decisions were based on ultrasound data, we used postoperative refraction measurements to calculate retrospectively what results would have been obtained if optical axial length data had been used for IOL calculation. For the translation of optical to geometrical lengths, five different conversion formulas were used, among them the relation which is built into the Zeiss IOL-Master. IOL calculation was carried out according to Haigis with and without optimization of constants. On the basis of ultrasound immersion data from our Grieshaber Biometric System (GBS), postoperative refraction after implantation of a Rayner IOL type 755 U was predicted correctly within +/- 1 D in 85.7% and within +/- 2 D in 99% of all cases. An analogous result was achieved with optical axial length data after suitable transformation of optical path lengths into geometrical distances. Partial coherence interferometry is a noncontact, user- and patient-friendly method for axial length determination and IOL planning with an accuracy comparable to that of high-precision immersion ultrasound.
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            Keratoconus: an inflammatory disorder?

            Keratoconus has been classically defined as a progressive, non-inflammatory condition, which produces a thinning and steepening of the cornea. Its pathophysiological mechanisms have been investigated for a long time. Both genetic and environmental factors have been associated with the disease. Recent studies have shown a significant role of proteolytic enzymes, cytokines, and free radicals; therefore, although keratoconus does not meet all the classic criteria for an inflammatory disease, the lack of inflammation has been questioned. The majority of studies in the tears of patients with keratoconus have found increased levels of interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α), and matrix metalloproteinase (MMP)-9. Eye rubbing, a proven risk factor for keratoconus, has been also shown recently to increase the tear levels of MMP-13, IL-6, and TNF-α. In the tear fluid of patients with ocular rosacea, IL-1α and MMP-9 have been reported to be significantly elevated, and cases of inferior corneal thinning, resembling keratoconus, have been reported. We performed a literature review of published biochemical changes in keratoconus that would support that this could be, at least in part, an inflammatory condition.
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              An improved universal theoretical formula for intraocular lens power prediction.

              G Barrett (1993)
              Although available empirically derived and theoretical formulas perform adequately for eyes of average axial length, both have been shown to be deficient for eyes that have unusually short and long axial lengths. I developed a formula based on a theoretical model eye in which anterior chamber depth is related to axial length and keratometry. A relationship between the A-constant and a "lens factor" is also used to determine anterior chamber depth. The location of the intraocular lens' principle planes of refraction is retained as a relevant variable in the formula, and the user need not know the material and construction of the lens and or its constant. I compared the new formula with the SRK II, Holladay, and SRK/T formulas in a group of 100 unselected patients and in selected subgroups of patients with average, short, and long axial lengths. The new formula was significantly more accurate than the other third-generation formulas and maintained its accuracy in the subgroups. The formula can be described as universal because it can be used for different lens styles and for eyes with short, medium, and long axial lengths.
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                Author and article information

                Contributors
                Journal
                J Curr Ophthalmol
                J Curr Ophthalmol
                Journal of Current Ophthalmology
                Elsevier
                2452-2325
                15 March 2019
                June 2019
                15 March 2019
                : 31
                : 2
                : 127-134
                Affiliations
                [a ]Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
                [b ]Nikookari Eye Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
                Author notes
                []Corresponding author. Eye Research Center, Rassoul Akram Hospital, Niayesh Avenue, Sattarkhan Street, Tehran 1445613131, Iran. drnavidmanafi@ 123456gmail.com
                Article
                S2452-2325(18)30102-1
                10.1016/j.joco.2019.01.011
                6611933
                31317089
                695d205f-ba6a-46bd-a5cf-7b5ee9a32622
                © 2019 Iranian Society of Ophthalmology. Production and hosting by Elsevier B.V.

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 4 May 2018
                : 11 January 2019
                : 24 January 2019
                Categories
                Article

                intraocular lens power,cataract,keratoconus,keratoconic,corneal ectasia

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