Concurrence of multiple sclerosis and amyotrophic lateral sclerosis in patients with hexanucleotide repeat expansions of C9ORF72.

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Abstract

Crossover in the pathogenic mechanisms of amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) has been described but is poorly understood. A GGGGCC hexanucleotide repeat expansion of C9ORF72 has recently been identified in a significant proportion of patients with ALS.

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Journal

Journal ID (iso-abbrev): J Neurol Neurosurg Psychiatry

Title: Journal of neurology, neurosurgery, and psychiatry

Publisher: BMJ

ISSN (Electronic): 1468-330X

ISSN (Print): 0022-3050

Publication date (Electronic): Jan 2013

Volume: 84

Issue: 1

Affiliations

[1 ] Academic Neurology Unit, Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385A Glossop Road, Sheffield S10 2HQ, UK.

Article

Publisher Item ID: jnnp-2012-303326

DOI: 10.1136/jnnp-2012-303326

PubMed ID: 23085936

SO-VID: 66d1af03-f010-4bdb-bc18-6b322760b634

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