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      Avaliação clínica e radiográfica da influência do fenobarbital (Gardenal®) na movimentação ortodôntica: estudo em coelhos Translated title: Clinical and radiographic evaluation of phenobarbital (Gardenal®) influence on orthodontic movement: a study in rabbits

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          Abstract

          OBJETIVO: Deste estudo foi avaliar clínica e radiograficamente a influência do Fenobarbital na movimentação ortodôntica. METODOLOGIA: Foram utilizados 22 coelhos da raça Nova Zelândia (Oryctolagus cuniculus), distribuídos em três grupos: normal (N), controle (C) e experimental (E). O grupo N (n=2) não foi tratado, apenas certificada a condição de normalidade. Nos grupos C (n=10) e E (n=10), foi montado aparelho ortodôntico entre os primeiros molares e incisivos inferiores para promover a movimentação para mesial dos molares. No grupo E, foi administrado conjuntamente à movimentação dentária induzida, o medicamento Fenobarbial. Após os períodos de 7 e 14 dias os animais foram sacrificados para análise clínica e radiográfica. CONCLUSÕES: Os resultados demonstraram não haver diferenças na extensão do movimento nem alterações radiográficas entre os animais do grupo controle e experimental.

          Translated abstract

          The objective of the present study was to evaluate the clinical and radiographic phenobarbital influence on orthodontic movement. 22 New Zealand rabbits (Oryctolagus cuniculus) have been used for study, all divided into three groups: N = normal rabbits; C = control rabbits; and E = experimental rabbits. No procedure was performed in Group N (n = 2), except a certification of the normal condition. In Groups C (n = 10) and E (n = 10), orthodontic device was placed between the lower first molars and the lower incisors in order to promote a mesial molar movement. In Group E, phenobarbital was administered together the treatment. Following the periods of 7 and 14 days, the animals were sacrificed for clinical and radiographic analysis. By comparing the control animals with the experimental ones, the results showed no difference on the rate of orthodontic tooth moment as well no radiographic change.

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          Clinical and histologic observations on tooth movement during and after orthodontic treatment.

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            Clinical application of prostaglandin E1 (PGE1) upon orthodontic tooth movement.

            Chemically produced prostaglandin E1 (PGE1) was administered in clinical cases of orthodontic tooth movement. In the first phase, lingual arch springs were applied on both sides of the maxilla to upper first premolars which were scheduled for extraction. One side received submucosal injections of PGE1 and the other received vehicle injections. The rate of tooth movement in the buccal direction approximately doubled on the side of several PGE1 injections as compared to the control side. In the second phase, the PGE1 injections were applied in canine-retraction cases for up to 3 weeks in first-premolar-extraction cases. The rate of distal canine movement was almost double on the side receiving PGE1 injections as compared to the vehicle-injected side. In the third phase, the PGE1 injections were applied on routine canine retraction in first-premolar-extraction cases. The rate of distal canine movement was almost 1.6-fold on the side of PGE1 injections as compared to the vehicle-injected side. Throughout this study, no side effects were observed macroscopically in the gingiva and roentgenographically in the alveolar bone, except for a slight pain reaction consistent with orthodontic tooth movement.
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              The effects of exogenous prostaglandins on orthodontic tooth movement in rats.

              The long-term effects of varying concentrations and frequencies of injectable, exogenous prostaglandin E2 (PGE2) on the rate of tooth movement and the amount of root resorption were evaluated. There were 132 male Sprague-Dawley rats 8 weeks old that initially weighed 225 to 250 gm. Five animals were in a pilot study, while seven were baseline controls and eight were appliance controls. The remaining 112 animals were divided into two experimental time periods of 2 and 4 weeks. Then, each experimental time period was divided into four subgroups of 14 animals based on concentration levels of PGE2 injections, i.e., 0.1, 1.0, 5.0 and 10.0 micrograms. Half of these animals in the dosage subgroup received a single injection at appliance placement and the other half received weekly injections. A fixed orthodontic appliance consisting of closed-coil nickel-titanium springs were ligated between the maxillary incisors and maxillary first molars. The initial activating force was 60 gm. The results showed that injections of exogenous PGE2 over an extended period of time in rats did enhance the amount of orthodontic tooth movement. However, there was no statistically significant difference in tooth movement between the single and multiple injection groups or among the four concentration levels of PGE2 used in either the 2- or 4-week time periods. The amount of root resorption as seen from scanning electron micrographs did increase with the use of prostaglandin injections, specifically with increased numbers of injections and with increased concentrations of PGE2.
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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Journal
                dpress
                Revista Dental Press de Ortodontia e Ortopedia Facial
                Rev. Dent. Press Ortodon. Ortop. Facial
                Dental Press Editora (Maringá )
                1980-5500
                February 2008
                : 13
                : 1
                : 34-42
                Affiliations
                [1 ] Universidade Federal de Alfenas
                [2 ] Universidade Federal do Rio de Janeiro Brazil
                Article
                S1415-54192008000100005
                10.1590/S1415-54192008000100005
                656a99c6-1628-4405-a3ae-75901e163093

                http://creativecommons.org/licenses/by/4.0/

                History
                Product

                SciELO Brazil

                Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=1415-5419&lng=en
                Categories
                DENTISTRY, ORAL SURGERY & MEDICINE

                Dentistry
                Tooth movement,Drug,Orthodontic,Movimentação dentária,Medicamentos,Ortodontia
                Dentistry
                Tooth movement, Drug, Orthodontic, Movimentação dentária, Medicamentos, Ortodontia

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