Onychogryphosis Is Associated with Dermatologic and Vascular Disease: A Case-Control Study of the All of Us Research Program

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Abstract

Introduction

Onychogryphosis is a nail condition characterized clinically by a thickened, curved, yellow-brown, and opaque nail plate and may result in pain, paronychia, and onychogryphosis.

Methods

We performed a nested case-control study of 1,114 onychogryphosis patients and 3,423 matched controls to quantify the association between onychogryphosis and self-care limitations, chronic foot injury, dermatologic conditions, and vascular disease.

Results and Conclusion

Onychogryphosis was positively associated with increased age, activity limitations (difficulty running errands alone, bathing, and concentrating), psoriasis, onychomycosis, hallux malleus, hallux valgus, peripheral vascular disease, lower extremity ulcers, venous varices, and type II diabetes mellitus. Therefore, physicians should screen patients presenting with onychogryphosis for these conditions.

Related collections

Most cited references 24

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The “All of Us” Research Program

(2019)

Knowledge gained from observational cohort studies has dramatically advanced the prevention and treatment of diseases. Many of these cohorts, however, are small, lack diversity, or do not provide comprehensive phenotype data. The All of Us Research Program plans to enroll a diverse group of at least 1 million persons in the United States in order to accelerate biomedical research and improve health. The program aims to make the research results accessible to participants, and it is developing new approaches to generate, access, and make data broadly available to approved researchers. All of Us opened for enrollment in May 2018 and currently enrolls participants 18 years of age or older from a network of more than 340 recruitment sites. Elements of the program protocol include health questionnaires, electronic health records (EHRs), physical measurements, the use of digital health technology, and the collection and analysis of biospecimens. As of July 2019, more than 175,000 participants had contributed biospecimens. More than 80% of these participants are from groups that have been historically underrepresented in biomedical research. EHR data on more than 112,000 participants from 34 sites have been collected. The All of Us data repository should permit researchers to take into account individual differences in lifestyle, socioeconomic factors, environment, and biologic characteristics in order to advance precision diagnosis, prevention, and treatment.

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Part I: Onychomycosis: Clinical Overview and Diagnosis

Shari R Lipner, Richard K. Scher (2018)

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Part II: Onychomycosis: Treatment and Prevention of Recurrence

Shari R Lipner, Richard K. Scher (2018)

Onychomycosis is a fungal nail infection caused by dermatophytes, nondermatophytes, and yeast, and is the most common nail disorder seen in clinical practice. It is an important problem because it may cause local pain, paresthesias, difficulties performing activities of daily living, and impair social interactions. The epidemiology, risk factors, and clinical presentation and diagnosis of onychomycosis were discussed in the first article in this continuing medical education series. In this article, we review the prognosis and response to onychomycosis treatment, medications for onychomycosis that have been approved by the US Food and Drug Administration, and off-label therapies and devices. Methods to prevent onychomycosis recurrences and emerging therapies are also described.

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Author and article information

Journal

Journal ID (nlm-ta): Skin Appendage Disord

Journal ID (iso-abbrev): Skin Appendage Disord

Journal ID (hwp): SAD

Journal ID (publisher-id): SAD

Title: Skin Appendage Disorders

Publisher: S. Karger AG (Basel, Switzerland )

ISSN (Print): 2296-9195

ISSN (Electronic): 2296-9160

Publication date (Electronic): 20 April 2023

Publication date (Print): August 2023

Volume: 9

Issue: 4

Pages: 252-257

Affiliations

[1]Weill Cornell Medical College, New York, NY, USA

Author notes

Correspondence to: Shari R. Lipner, shl9032@ 123456med.cornell.edu

Article

Publisher ID: 530096

DOI: 10.1159/000530096

PMC ID: 10410083

PubMed ID: 37564683

SO-VID: 64dd9892-1e1a-45d8-bbf1-a42690f753ca

License:

This article is licensed under the Creative Commons Attribution 4.0 International License (CC BY) ( http://www.karger.com/Services/OpenAccessLicense). Usage, derivative works and distribution are permitted provided that proper credit is given to the author and the original publisher.

History

Date received : 5 January 2023

Date accepted : 24 February 2023

Date: 2023

Page count

Figures: 1, Tables: 5, References: 25, Pages: 6

Funding

Z.C. was supported by an F30 predoctoral fellowship from the NIH/NCI (F30CA268747) and a Medical Scientist Training Program grant from the National Institute of General Medical Sciences of the National Institutes of Health under award number T32GM007739 to the Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program.