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Abstract
Onychomycosis is a fungal nail infection caused by dermatophytes, nondermatophytes,
and yeast, and is the most common nail disorder seen in clinical practice. It is an
important problem because it may cause local pain, paresthesias, difficulties performing
activities of daily living, and impair social interactions. The epidemiology, risk
factors, and clinical presentation and diagnosis of onychomycosis were discussed in
the first article in this continuing medical education series. In this article, we
review the prognosis and response to onychomycosis treatment, medications for onychomycosis
that have been approved by the US Food and Drug Administration, and off-label therapies
and devices. Methods to prevent onychomycosis recurrences and emerging therapies are
also described.