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The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity.
Keith H Nuechterlein
1 ,
Michael F Green ,
Robert S Kern ,
Lyle E Baade ,
Deanna M Barch ,
Jonathan D Cohen ,
Susan Essock ,
Wayne S Fenton ,
Frederick J Frese ,
James M Gold ,
Terry Goldberg ,
Robert K Heaton ,
Richard S E Keefe ,
Helena Kraemer ,
Raquelle Mesholam-Gately ,
Larry J Seidman ,
Ellen Stover ,
Daniel R Weinberger ,
Alexander S Young ,
Steven Zalcman ,
Stephen R Marder
Feb 2008
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Abstract
The lack of an accepted standard for measuring cognitive change in schizophrenia has been a major obstacle to regulatory approval of cognition-enhancing treatments. A primary mandate of the National Institute of Mental Health's Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative was to develop a consensus cognitive battery for clinical trials of cognition-enhancing treatments for schizophrenia through a broadly based scientific evaluation of measures.