For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
13
views
32
references
 Top references
cited by
58
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      65
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: not found

      The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens.

      Author(s):
      Publication date:
      Journal: Nature immunology
      Keywords: Amino Acid Sequence, Animals, Cytokines, immunology, metabolism, Extracellular Matrix, Extracellular Matrix Proteins, genetics, Female, Gram-Negative Bacteria, pathogenicity, Gram-Negative Bacterial Infections, microbiology, Gram-Positive Bacteria, Gram-Positive Bacterial Infections, Humans, Lipopolysaccharides, Macrophages, Peritoneal, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Molecular Sequence Data, Teichoic Acids

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Microbial pathogens use a variety of their surface molecules to bind to host extracellular matrix (ECM) components to establish an effective infection. However, ECM components can also serve as an integral part of the innate immunity. Mice lacking expression of mindin (spondin 2), a highly conserved ECM protein, have an impaired ability to clear bacterial infection, and mindin-deficient macrophages show defective responses to a broad spectrum of microbial stimuli. Moreover, mindin binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Thus, mindin is essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens.

          Related collections

          Most cited references32

          • Record: found
          • Abstract: found
          • Article: not found

          Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

          Osamu Takeuchi, Katsuaki Hoshino, Taro Kawai … (1999)
          Toll-like receptor (TLR) 2 and TLR4 are implicated in the recognition of various bacterial cell wall components, such as lipopolysaccharide (LPS). To investigate in vivo roles of TLR2, we generated TLR2-deficient mice. In contrast to LPS unresponsiveness in TLR4-deficient mice, TLR2-deficient mice responded to LPS to the same extent as wild-type mice. TLR2-deficient macrophages were hyporesponsive to several Gram-positive bacterial cell walls as well as Staphylococcus aureus peptidoglycan. TLR4-deficient macrophages lacked the response to Gram-positive lipoteichoic acids. These results demonstrate that TLR2 and TLR4 recognize different bacterial cell wall components in vivo and TLR2 plays a major role in Gram-positive bacterial recognition.
          Article 0 comments Cited 573 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Phylogenetic perspectives in innate immunity.

            J A Hoffmann, F C Kafatos, C A Janeway … (1999)
            The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.
            Article 0 comments Cited 337 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Toll-like receptor signaling pathways.

              Gregory M Barton, Ruslan Medzhitov (2003)
              Members of the Toll-like receptor (TLR) family recognize conserved microbial structures, such as bacterial lipopolysaccharide and viral double-stranded RNA, and activate signaling pathways that result in immune responses against microbial infections. All TLRs activate MyD88-dependent pathways to induce a core set of stereotyped responses, such as inflammation. However, individual TLRs can also induce immune responses that are tailored to a given microbial infection. Thus, these receptors are involved in both innate and adaptive immune responses. The mechanisms and components of these varied responses are only partly understood. Given the importance of TLRs in host defense, dissection of the pathways they activate has become an important emerging research focus. TLRs and their pathways are numerous; Science's Signal Transduction Knowledge Environment's TLR Connections Map provides an immediate, clear overview of the known components and relations of this complex system.
              Article 0 comments Cited 284 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                PubMed ID:: 14691481
                DOI:: 10.1038/ni1021

                ScienceOpen disciplines: Chemistry
                Keywords: Amino Acid Sequence,Animals,Cytokines,immunology,metabolism,Extracellular Matrix,Extracellular Matrix Proteins,genetics,Female,Gram-Negative Bacteria,pathogenicity,Gram-Negative Bacterial Infections,microbiology,Gram-Positive Bacteria,Gram-Positive Bacterial Infections,Humans,Lipopolysaccharides,Macrophages, Peritoneal,Male,Mice,Mice, Inbred C57BL,Mice, Knockout,Molecular Sequence Data,Teichoic Acids
                Data availability:
                ScienceOpen disciplines: Chemistry
                Keywords: Amino Acid Sequence, Animals, Cytokines, immunology, metabolism, Extracellular Matrix, Extracellular Matrix Proteins, genetics, Female, Gram-Negative Bacteria, pathogenicity, Gram-Negative Bacterial Infections, microbiology, Gram-Positive Bacteria, Gram-Positive Bacterial Infections, Humans, Lipopolysaccharides, Macrophages, Peritoneal, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Molecular Sequence Data, Teichoic Acids

                Comments

                Comment on this article

                scite_

                Similar content65

                See all similar

                Cited by55

                See all cited by

                Most referenced authors1,171

                See all reference authors