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      Allergen immunotherapy for allergic rhinoconjunctivitis: a systematic review and meta-analysis.

      1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 15 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 28 , 29 , 30 , 15 , 31 , 32 , 33 , 34 , 35 , 36 , 36 , 37 , 38 , 39 , 40
      Allergy
      Wiley-Blackwell
      Allergen, Allergy, allergen immunotherapy, allergic rhinoconjuctivitis, desensitization, rhinitis, subcutaneous, sublingual

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          Abstract

          The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing Guidelines on Allergen Immunotherapy (AIT) for Allergic Rhinoconjunctivitis. In order to inform the development of clinical recommendations, we undertook a systematic review to assess the effectiveness, cost-effectiveness and safety of AIT in the management of allergic rhinoconjunctivitis METHODS: We searched 15 international biomedical databases for published, in progress and unpublished evidence. Studies were independently screened by two reviewers against pre-defined eligibility criteria and critically appraised using established instruments. Our primary outcomes of interest were symptom, medication and combined symptom and medication scores. Secondary outcomes of interest included cost-effectiveness and safety. Data were descriptively summarized and then quantitatively synthesized using random-effects meta-analyses.

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          Author and article information

          Journal
          Allergy
          Allergy
          Wiley-Blackwell
          1398-9995
          0105-4538
          May 11 2017
          Affiliations
          [1 ] Evidence-Based Health Care Ltd, Edinburgh, UK.
          [2 ] Cardiff University, School of Medicine, Division of Population Medicine Neuadd Meirionnydd, Heath Park, Cardiff, UK.
          [3 ] Department of Pediatrics, Allergy Unit, University of Messina, Italy & Molecular Allergology and Immunomodulation-Department of Pediatric Pneumology and Immunology, Charité Medical University, Augustenburger Platz 1, Berlin, Germany.
          [4 ] School of Pharmacy, Monash University, Malaysia.
          [5 ] Centre for Health Economics, University of York, UK.
          [6 ] Bradford School of Pharmacy, UK.
          [7 ] School of Medicine, University of Toronto, Canada.
          [8 ] Institute for Health and Human Development, University of East London, UK.
          [9 ] The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Newport Isle of Wight, NIHR Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
          [10 ] Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
          [11 ] Faculty of Medicine, University of Southampton, Southampton, UK.
          [12 ] Center for Rhinology and Allergology, Wiesbaden, Germany.
          [13 ] Food Allergy Referral Centre Veneto Region Department of Women and Child Health Padua General University Hospital, Italy.
          [14 ] Hospital Quiron Bizkair, Bilbao, Spain.
          [15 ] National Heart and Lung Institute, Imperial College, London, UK.
          [16 ] Department of ENT, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey.
          [17 ] Section of Allergology, Department of Internal Medicine, Erasmus MC Rotterdam, The Netherlands.
          [18 ] Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
          [19 ] Children's Center Bethel, EvKB, Bieledelf and Allergy Center Buhr-University, Bochum, Germany.
          [20 ] Laboratory of Experimental Immunology, University Hospitals Leuven, Belgium.
          [21 ] ALC, Allergy Learning and Consulting.
          [22 ] University Medical Center, Utrecht, The Netherlands.
          [23 ] Hospital Medica Sur, Mexico City, Mexico.
          [24 ] Department of Otolaryngology-Head & Neck Surgery, John Hopkins, USA.
          [25 ] Allergy and Clinical Immunology Unit, 2nd Department of Pediatrics, University of Athens, P&A Kiriakou Children's Hospital, Athens, Greece.
          [26 ] University Medical Center Groningen, University of Groningen, Department of Allergology, Groningen Research Institute for Asthma and COPD (GRIAC),, Groningen, Netherlands.
          [27 ] University Medical Center of Groningen, University of Groningen, Groningen, The Netherlands.
          [28 ] Department of Pediatrics, University of Messina, Italy.
          [29 ] Department of Pediatrics, Nippon Medical School, Tokyo, Japan.
          [30 ] University of Milano, Italy.
          [31 ] The Royal National Throat, Nose and Ear Hospital, University College London, London, UK.
          [32 ] Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
          [33 ] Netherlands Anafylaxis Network, The Netherlands.
          [34 ] Charite University Hospital, Berlin, Germany.
          [35 ] Dept. of Paediatrics, Respiratory and Allergic Disease Division. Medical University Graz, Graz, Austria.
          [36 ] Pharmaceutical Group of the European Union, Brussels, Belgium.
          [37 ] Guy's and St Thomas' NHS Foundation Trust, London, UK.
          [38 ] Chartie-Universitatsmedizin, Berlin, Germany.
          [39 ] Beijing Institute of Otolarygology, Beijing, China.
          [40 ] Asthma UK Centre for Applied Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK.
          Article
          10.1111/all.13201
          28493631
          5f4b2a6d-cc93-4fd6-b910-c4f91df3dd85
          History

          Allergen,Allergy,allergen immunotherapy,allergic rhinoconjuctivitis,desensitization,rhinitis,subcutaneous,sublingual

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