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Abstract
Altered lipid metabolism is among the most prominent metabolic alterations in cancer.
Enhanced synthesis or uptake of lipids contributes to rapid cancer cell growth and
tumor formation. Lipids are a highly complex group of biomolecules that not only constitute
the structural basis of biological membranes but also function as signaling molecules
and an energy source. Here, we summarize recent evidence implicating altered lipid
metabolism in different aspects of the cancer phenotype and discuss potential strategies
by which targeting lipid metabolism could provide a therapeutic window for cancer
treatment.