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Abstract

How do individual cells organize into multicellular tissues? Here, we propose that the morphogenetic behaviour of epithelial cells is guided by two distinct elements: an intrinsic differentiation programme that drives formation of a lumen-enclosing monolayer, and a growth factor-induced, transient de-differentiation that allows this monolayer to be remodelled.

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PubMed ID:: 12094219

DOI:: 10.1038/nrm859

ScienceOpen disciplines: Chemistry

Keywords: Animals,Cell Communication,Cell Culture Techniques,methods,Cell Differentiation,Cell Division,drug effects,Epithelial Cells,cytology,Hepatocyte Growth Factor,pharmacology,Humans,Morphogenesis

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ScienceOpen disciplines: Chemistry

Keywords: Animals, Cell Communication, Cell Culture Techniques, methods, Cell Differentiation, Cell Division, drug effects, Epithelial Cells, cytology, Hepatocyte Growth Factor, pharmacology, Humans, Morphogenesis

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