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      A rare case report of endometrial adenosarcoma in the cesarean scar diverticulum

      case-report

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          Abstract

          Background

          Endometrial adenosarcoma is an unusual type of uterine tumor that features a seemingly benign epithelial component, paired with a low-grade sarcomatous component, usually similar in appearance to endometrial stromal sarcoma. To our knowledge, no image of endometrial adenocarcinoma in the cesarean scar diverticulum has been reported previously.

          Case Description

          We present a rare case of endometrial adenocarcinoma located in the cesarean scar diverticulum of a 44-year-old patient. The patient was admitted to our hospital complaining of irregular vaginal bleeding that had lasted for over two months. Both B-ultrasound and magnetic resonance imaging confirmed a mass at the junction of the corpus uteri and cervix. After the initial curettage failed to confirm the disease, a hysteroscopy was subsequently performed. Upon further pathological analysis, a diagnosis of endometrial adenosarcoma was confirmed. The patient underwent hysterectomy and salpingo-oophorectomy. The patient was discharged home four days after the surgery and remained recurrence-free for one year after follow-up.

          Conclusions

          Hysteroscopy can serve as a valuable diagnostic tool to identify the lesion in this unique scenario, particularly when curettage fails to diagnose this uncommon condition. We hope that this case would bring awareness of this potential scenario, enabling clinicians in the future to identify similar cases more readily.

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          Most cited references4

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          Uterine adenosarcoma: a case report and review of the literature.

          Uterine adenosarcoma is a rare gynecological malignancy with no specific symptoms, and the optimal management is still inconclusive. Herein we present a case of uterine adenosarcoma in a 38-year-old woman with a good prognosis and review of literatures. The patient presented with abnormal vaginal bleeding with no special medical history. Sonographic scan revealed a heterogeneous echoic mass in the cavity, indicating a polypus or a submucous myoma. The pathology based on the specimen after the hysteroscopic tumor excision suggested diagnosis of uterine adenosarcoma. Subsequently, the patient received pelvic MRI scan before surgery. MRI identified a patchy lesion at the cervix-lower endometrial cavity with low signal in T1WI and a mixed high T2 signal in T2WI, with no sign of metastasis. Then total abdominal hysterectomy with bilateral salpingo-oopherectomy plus pelvic lymph node dissection was performed and 6 cycles of chemotherapy were administered. The patient remains disease-free on follow-up to date, more than 15 months after chemotherapy.
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            Diagnostic accuracy of MRI in the differential diagnosis between uterine leiomyomas and sarcomas: A systematic review and meta‐analysis

            Background Differential diagnosis between uterine leiomyomas and sarcomas is challenging. Magnetic resonance imaging (MRI) represents the second‐line diagnostic method after ultrasound for the assessment of uterine masses. Objectives To assess the accuracy of MRI in the differential diagnosis between uterine leiomyomas and sarcomas. Search Strategy A systematic review and meta‐analysis was performed searching five electronic databases from their inception to June 2023. Selection Criteria All peer‐reviewed observational or randomized clinical trials that reported an unbiased postoperative histologic diagnosis of uterine leiomyoma or uterine sarcoma, which also comprehended a preoperative MRI evaluation of the uterine mass. Data Collection and Analysis Sensitivity, specificity, positive and negative likelihood ratios, diagnostic odds ratio, and area under the curve on summary receiver operating characteristic of MRI in differentiating uterine leiomyomas and sarcomas were calculated as individual and pooled estimates, with 95% confidence intervals (CI). Results Eight studies with 2495 women (2253 with uterine leiomyomas and 179 with uterine sarcomas), were included. MRI showed pooled sensitivity of 0.90 (95% CI 0.84–0.94), specificity of 0.96 (95% CI 0.96–0.97), positive likelihood ratio of 13.55 (95% CI 6.20–29.61), negative likelihood ratio of 0.08 (95% CI 0.02–0.32), diagnostic odds ratio of 175.13 (95% CI 46.53–659.09), and area under the curve of 0.9759. Conclusions MRI has a high diagnostic accuracy in the differential diagnosis between uterine leiomyomas and sarcomas. This meta‐analysis assesses the accuracy of MRI in the differential diagnosis between uterine leiomyomas and sarcomas, demonstrating a very high diagnostic accuracy.
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              Prevalence of sonographic signs in women with uterine sarcoma: a systematic review and meta-analysis.

              To assess the prevalence of sonographic signs in women with uterine sarcoma.
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                Author and article information

                Journal
                Transl Cancer Res
                Transl Cancer Res
                TCR
                Translational Cancer Research
                AME Publishing Company
                2218-676X
                2219-6803
                28 May 2024
                31 May 2024
                : 13
                : 5
                : 2561-2563
                Affiliations
                [1 ]deptDepartment of Obstetrics and Gynecology, West China Second Hospital , Sichuan University , Chengdu, China;
                [2 ]deptKey Laboratory of Birth defects and Related Diseases of Women and Children, Ministry of Education , Sichuan University , Chengdu, China
                Author notes

                Contributions: (I) Conception and design: L Han, J Ruan; (II) Administrative support: None; (III) Provision of study materials or patients: G Shi; (IV) Collection and assembly of data: None; (V) Data analysis and interpretation: None; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

                Correspondence to: Jiaying Ruan, MD. Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Renmin South Road, Chengdu 610041, China; Key Laboratory of Birth defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China. Email: 13980079129@ 123456163.com .
                Article
                tcr-13-05-2561
                10.21037/tcr-23-2155
                11170518
                5a9e6c09-32e9-4320-80b3-b0a9bd8f87c7
                2024 Translational Cancer Research. All rights reserved.

                Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

                History
                : 22 November 2023
                : 10 April 2024
                Categories
                Case Report

                endometrial adenosarcoma,cesarean scar diverticulum,case report

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