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      A novel microRNA panel exhibited significant potential in evaluating the progression of laryngeal squamous cell carcinoma

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          Abstract

          Background

          Laryngeal squamous cell carcinoma (LSCC) is a common cancer of the head and neck in humans. The 5-years survival rate of patients with LSCC have declined in the past four decades. microRNAs (miRNAs) has been reported to be capable of predicting the prognosis outcomes of patients with different cancers. However, there are no reports on the usage of multi-miRNAs model as signature for the diagnosis or prognosis of LSCC.

          Methods

          To establish the miRNAs expression-associated model for diagnosis, prognosis prediction and aided therapy of patients with LSCC, the present study enrolled 107 patients with LSCC in clinic and obtained 117 LSCC samples data from TCGA database for evaluation, respectively. Next generation sequencing (NGS), raw data processing, the least absolute shrinkage and selection operator algorithm, Cox regression analysis, construction of nomogram and cell function assays (including proliferation, migration and invasion assays) were sequentially performed.

          Results

          There were massively dysregulated miRNAs in the LSCC compared to normal tissues. A six-miRNAs signature consists of miR-137–3p, miR-3934–5p, miR-1276, miR-129–5p, miR-7-5p and miR-105–5p was built for prognosis prediction of LSCC patients. The six-miRNAs signature is strongly associated with the poor overall survival (OS, p = 2.5e-05, HR: 4.30 [2.20–8.50]), progression free interval (PFI, p = 0.025, HR: 1.94 [1.08–3.46]) and disease specific survival (DSS, p = 1.1e-05, HR: 5.00 [2.50–10.00]). A nomogram for prediction of 2-, 3- and 5-years OS was also developed based on the six-miRNAs signature and clinical features. Furthermore, blocking the function of each of the six miRNAs inhibited proliferation, invasion and migration of LSCC cells.

          Conclusions

          The performance of six-miRNAs signature described in the current study demonstrated remarkable potential for progression assessment of LSCC. Moreover, the six-miRNAs signature may serve as predictive tool for prognosis and therapeutic targets of LSCC in clinic.

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          Most cited references47

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          Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017

          This systematic analysis describes cancer burden for 29 cancer groups across 195 countries from 1990 through 2017 to provide data needed for cancer control planning.
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            Proliferation, cell cycle and apoptosis in cancer.

            Beneath the complexity and idiopathy of every cancer lies a limited number of 'mission critical' events that have propelled the tumour cell and its progeny into uncontrolled expansion and invasion. One of these is deregulated cell proliferation, which, together with the obligate compensatory suppression of apoptosis needed to support it, provides a minimal 'platform' necessary to support further neoplastic progression. Adroit targeting of these critical events should have potent and specific therapeutic consequences.
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              RNA-Targeted Therapeutics

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                Author and article information

                Contributors
                Journal
                Noncoding RNA Res
                Noncoding RNA Res
                Non-coding RNA Research
                KeAi Publishing
                2468-0540
                04 August 2023
                December 2023
                04 August 2023
                : 8
                : 4
                : 550-561
                Affiliations
                [a ]Department of Thyroid Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, Zhejiang, PR China
                [b ]Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, PR China
                [c ]Shenzhen Eye Institute, Shenzhen Eye Hospital, Shenzhen, 518040, Guangdong, PR China
                [d ]Department of Otolaryngology Head & Neck Surgery, First Hospital of Jinzhou Medical University, Jinzhou, 121011, Liaoning, PR China
                [e ]Department of Otolaryngology Head & Neck Surgery, Shanxi Bethune Hospital, Taiyuan, 030032, Shanxi, PR China
                [f ]Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, Guangdong, PR China
                [g ]Department of Hepatobiliary Surgery, Shenzhen University General Hospital & Shenzhen University Clinical Medical Academy Center, Shenzhen University, Shenzhen, 518055, Guangdong, PR China
                [h ]Department of Otolaryngology Head & Neck Surgery, Longgang Ear-Nose-Throat Hospital, Shenzhen, 518172, Guangdong, PR China
                [i ]Shenzhen Institute of Otolaryngology & Key Laboratory of Otolaryngology, Longgang Ear-Nose-Throat Hospital, Shenzhen, 518172, Guangdong, PR China
                Author notes
                []Corresponding author. Department of Otolaryngology Head & Neck Surgery, Longgang Ear-Nose-Throat Hospital, Shenzhen, 518172, Guangdong, PR China gaoweisxent@ 123456sxent.org
                [∗∗ ]Corresponding author. Department of Thyroid Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, Zhejiang, PR China. p.wang@ 123456zju.edu.cn
                [∗∗∗ ]Corresponding author. Department of Otolaryngology Head & Neck Surgery, Longgang Ear-Nose-Throat Hospital, Shenzhen, 518172, Guangdong, PR China. wuyongyan@ 123456sxent.org
                [1]

                These authors contributed equally to this work.

                Article
                S2468-0540(23)00048-3
                10.1016/j.ncrna.2023.08.001
                10432973
                37602318
                59b506e7-4743-4477-ba96-cda8f9b6e88c
                © 2023 The Authors

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 7 June 2023
                : 2 August 2023
                : 2 August 2023
                Categories
                Original Research Article

                microrna,molecular biomarkers,otorhinolaryngology head and neck surgery,laryngeal squamous cell carcinoma,prognosis prediction,overall survival,oncogene

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