Sirt1 suppresses MCP-1 production during the intervertebral disc degeneration by inactivating AP-1 subunits c-Fos/c-Jun.

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Abstract

The anti-inflammatory effect of Sirtuin 1 (Sirt1) during intervertebral disc degeneration (IDD) has been widely confirmed. Monocyte chemoattractant protein-1 (MCP-1) activation is the initiating inflammatory response associated with the IDD. However, whether Sirt1 suppresses MCP-1 in the intervertebral disc is unclear.

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Journal

Journal ID (iso-abbrev): Eur Rev Med Pharmacol Sci

Title: European review for medical and pharmacological sciences

Publisher:

ISSN (Electronic): 2284-0729

ISSN (Print): 1128-3602

Publication date (Electronic): June 2020

Volume: 24

Issue: 11

Affiliations

[1 ] Department of Spinal Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China. cwt7724@126.com.

Article

DOI: 10.26355/eurrev_202006_21482

PubMed ID: 32572902

SO-VID: 5970ebe4-e6c5-47fe-aaab-4d3a27c20f93

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