Neuroinflammation pathways: a general review.

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Abstract

Activated microglial cells play an important role in immune and inflammatory responses in central nervous system and neurodegenerative diseases. Many pro-apoptotic pathways are mediated by signaling molecules that are produced during neuroinflammation. In glial cells, NF-κB, a transcription factor, initiates and regulates the expression of several inflammatory processes during inflammation which are attributed to the pathology of the several neurodegenerative diseases. In this review, we discuss the most important neuroinflammatory mediators with their pathways. Attenuating cytokines production and controlling microglial inflammatory response, which are the result of understanding neuroinflammation pathways, are considered therapeutic strategies for treating neurodegenerative diseases with an inflammatory component.

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Author and article information

Journal

Journal ID (iso-abbrev): Int. J. Neurosci.

Title: The International journal of neuroscience

Publisher: Informa UK Limited

ISSN (Electronic): 1563-5279

ISSN (Print): 0020-7454

Publication date (Electronic): Jul 2017

Volume: 127

Issue: 7

Affiliations

[1 ] a Faculty of Science, Biomolecular Research Group, Biochemistry Program , Institute of Biological Sciences, University of Malaya , Kuala Lumpur , Malaysia.

[2 ] b Department of Obstetrics and Gynaecology, Royal Women's Hospital , University of Melbourne , Parkville , Australia.

[3 ] c Department of Perinatal Medicine, Pregnancy Research Centre , Royal Women's Hospital , Parkville , Australia.

Article

DOI: 10.1080/00207454.2016.1212854

PubMed ID: 27412492

SO-VID: 53cc2e8c-1c6d-4de0-9d7d-2992ea27156f

History

Keywords: NF-κB pathway,microglia,neuroinflammation,neuroinflammatory diseases

Data availability:

Keywords: NF-κB pathway, microglia, neuroinflammation, neuroinflammatory diseases

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