Successful pediatric heart transplantation from a deceased donor with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection “Case report”

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Abstract

We report the case of a 3-year-old, who was highly sensitized and who received a cardiac transplantation from a donor in the acute phase of SARS-CoV-2 infection. Despite maximal immunosuppression due to a positive cross match and desensitization protocol, the patient's course was favorable.

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Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

Xin Zou, Ke Chen, Jiawei Zou … (2020)

It has been known that, the novel Coronavirus, 2019-nCoV, which is considered similar to SARS-CoV and originated from Wuhan (China), invades human cells via the receptor angiotensin converting enzyme II (ACE2). Moreover, lung cells that have ACE2 expression may be the main target cells during 2019-nCoV infection. However, some patients also exhibit non-respiratory symptoms, such as kidney failure, implying that 2019-nCoV could also invade other organs. To construct a risk map of different human organs, we analyzed the single-cell RNA sequencing (scRNA-seq) datasets derived from major human physiological systems, including the respiratory, cardiovascular, digestive, and urinary systems. Through scRNA-seq data analyses, we identified the organs at risk, such as lung, heart, esophagus, kidney, bladder, and ileum, and located specific cell types (i.e., type II alveolar cells (AT2), myocardial cells, proximal tubule cells of the kidney, ileum and esophagus epithelial cells, and bladder urothelial cells), which are vulnerable to 2019-nCoV infection. Based on the findings, we constructed a risk map indicating the vulnerability of different organs to 2019-nCoV infection. This study may provide potential clues for further investigation of the pathogenesis and route of 2019-nCoV infection. Electronic Supplementary Material Supplementary material is available for this article at 10.1007/s11684-020-0754-0 and is accessible for authorized users.

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Potential Effects of Coronaviruses on the Cardiovascular System: A Review

Mohammad Madjid, Payam Safavi-Naeini, Scott Solomon … (2020)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19) has reached a pandemic level. Coronaviruses are known to affect the cardiovascular system. We review the basics of coronaviruses, with a focus on COVID-19, along with their effects on the cardiovascular system.

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SARS-CoV-2 viremia is associated with distinct proteomic pathways and predicts COVID-19 outcomes

Yijia Li, Alexis Schneider, Arnav Mehta … (2021)

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Author and article information

Journal

Journal ID (nlm-ta): Transplant Proc

Journal ID (iso-abbrev): Transplant Proc

Title: Transplantation Proceedings

Publisher: Elsevier Inc.

ISSN (Print): 0041-1345

ISSN (Electronic): 1873-2623

Publication date PMC-release: 28 June 2023

Publication date (Electronic): 28 June 2023

Affiliations

[0001]Department of pediatrics, University Hospital Center Sainte-Justine (CHUSJ), Montreal, 3175 chemin de la Côte Sainte-Catherine, H3T 1C5, Montreal, Canada

Author notes

[* ]Corresponding author: David Bienjonetti-Boudreau; Montreal University, 3175 chemin de la Côte Sainte-Catherine, H3T 1C5, Montreal, Canada, 581-308-4348

Article

Publisher Item ID: S0041-1345(23)00455-4

DOI: 10.1016/j.transproceed.2023.06.010

PMC ID: 10300283

SO-VID: 51ac7a7a-baaf-4d89-ac60-e0f8bb4929c6

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Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

Successful pediatric heart transplantation from a deceased donor with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection “Case report”

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Novel Coronavirus Disease COVID-19

Most cited references 15

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

Potential Effects of Coronaviruses on the Cardiovascular System: A Review

SARS-CoV-2 viremia is associated with distinct proteomic pathways and predicts COVID-19 outcomes

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