Abstract. Objective: In cancer care, phytopharmaceuticals are used to treat cancer-related symptoms or side effects related to conventional cancer treatment. Herbal extracts are complex mixtures of several substances and therefore the safety and efficacy of an herbal extract is the sum of actions and interactions of all its ingredients. Phytotherapy may have a positive effect on cancer-related symptoms and side effects of conventional treatments. Effectiveness, efficacy, and safety of most herbal treatments remain uncertain. Material and methods: This review will consider studies that include adult patients with all types of cancer and all studies providing data on herbal medicine as intervention if used for medicinal purposes or taken as supplements. Control interventions eligible for the planned review will be all therapy options at the particular treatment stage. All outcomes chosen in the included studies will be discussed concerning their clinical relevance and their relevance to the patient. It will consider both experimental and epidemiological study designs. The search strategy aims to find evidence published in journals and grey literature. The reporting will follow the PRISMA statement. Results: Based on an initial search ~ 16,000 search results are estimated for title/abstract screening. A preliminary search for systematic reviews on the topic revealed that the essential questions of the suggested review, which specific phytotherapy interventions and methods of delivery are most effective in cancer treatment and what are the characteristics of patients who benefit the most, have not been answered by any review yet. Conclusion: Regarding biological-based complementary and alternative medicine (CAM) and especially phytotherapy, benefits as well as risks from side effects and interactions must be considered. With an abundance of phytotherapeuticals existing, systematic reviews for often-used botanicals in cancer care may summarize evidence for physicians and other healthcare providers engaged in counseling individuals with cancer.