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      PRP for Degenerative Cartilage Disease: A Systematic Review of Clinical Studies

      1 , 1 , 2 , 3 , 4 , 5 , 6 , 7 , 2
      CARTILAGE
      SAGE Publications

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          Abstract

          To explore the utilization of platelet-rich plasma (PRP) for degenerative cartilage processes and evaluate whether there is sufficient evidence to better define its potential effects.

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          Most cited references34

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          Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF).

          The topical use of platelet concentrates is recent and its efficiency remains controversial. Several techniques for platelet concentrates are available; however, their applications have been confusing because each method leads to a different product with different biology and potential uses. Here, we present classification of the different platelet concentrates into four categories, depending on their leucocyte and fibrin content: pure platelet-rich plasma (P-PRP), such as cell separator PRP, Vivostat PRF or Anitua's PRGF; leucocyte- and platelet-rich plasma (L-PRP), such as Curasan, Regen, Plateltex, SmartPReP, PCCS, Magellan or GPS PRP; pure plaletet-rich fibrin (P-PRF), such as Fibrinet; and leucocyte- and platelet-rich fibrin (L-PRF), such as Choukroun's PRF. This classification should help to elucidate successes and failures that have occurred so far, as well as providing an objective approach for the further development of these techniques.
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            Platelet-rich plasma: from basic science to clinical applications.

            Platelet-rich plasma (PRP) has been utilized in surgery for 2 decades; there has been a recent interest in the use of PRP for the treatment of sports-related injuries. PRP contains growth factors and bioactive proteins that influence the healing of tendon, ligament, muscle, and bone. This article examines the basic science of PRP, and it describes the current clinical applications in sports medicine. This study reviews and evaluates the human studies that have been published in the orthopaedic surgery and sports medicine literature. The use of PRP in amateur and professional sports is reviewed, and the regulation of PRP by antidoping agencies is discussed.
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              Platelet-rich plasma: the PAW classification system.

              Platelet-rich plasma (PRP) has been the subject of hundreds of publications in recent years. Reports of its effects in tissue, both positive and negative, have generated great interest in the orthopaedic community. Protocols for PRP preparation vary widely between authors and are often not well documented in the literature, making results difficult to compare or replicate. A classification system is needed to more accurately compare protocols and results and effectively group studies together for meta-analysis. Although some classification systems have been proposed, no single system takes into account the multitude of variables that determine the efficacy of PRP. In this article we propose a simple method for organizing and comparing results in the literature. The PAW classification system is based on 3 components: (1) the absolute number of Platelets, (2) the manner in which platelet Activation occurs, and (3) the presence or absence of White cells. By analyzing these 3 variables, we are able to accurately compare publications. Copyright © 2012 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.
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                Author and article information

                Journal
                CARTILAGE
                CARTILAGE
                SAGE Publications
                1947-6035
                1947-6043
                September 2016
                October 2017
                September 2016
                October 2017
                : 8
                : 4
                : 341-364
                Affiliations
                [1 ]Department of Orthopaedics and Sports Medicine Service, “Meir” Medical Center and Tel-Aviv University Hospital, Kfar-Saba, Israel
                [2 ]O.A.S.I. Bioresearch Foundation Gobbi NPO, Milan, Italy
                [3 ]Sports Medicine and Hip Preservation Service, Department of Orthopedics, University of Colorado, Aurora, CO, USA
                [4 ]Orthopaedics Department of Minho University, Minho, Portugal
                [5 ]Clínica do Dragão—Espregueira-Mendes Sports Centre—FIFA Medical Centre of Excellence, Porto, Portugal
                [6 ]Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal
                [7 ]ICVS/3B’s PT Government Associate Laboratory, Braga, Guimarães, Portugal
                Article
                10.1177/1947603516670709
                5613892
                28317389
                507f966b-7dfd-4303-a0d3-6a24babf0cd5
                © 2017

                http://journals.sagepub.com/page/policies/text-and-data-mining-license

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