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Clinical outcome and gene- and microRNA-expression profiling according to the Wilms tumor 1 (WT1) single nucleotide polymorphism rs16754 in adult de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.
Heiko Becker
1 ,
Kati Maharry ,
Michael D Radmacher ,
Krzysztof Mrózek ,
Klaus H Metzeler ,
Susan P Whitman ,
Sebastian Schwind ,
Jessica Kohlschmidt ,
Yue-Zhong Wu ,
Bayard L Powell ,
Thomas H Carter ,
Jonathan E Kolitz ,
Meir Wetzler ,
Andrew J Carroll ,
Maria R Baer ,
Joseph O Moore ,
Michael A Caligiuri ,
Richard A Larson ,
Guido Marcucci ,
Clara D Bloomfield
Oct 2011
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Abstract
The alleles of the Wilms tumor 1 (WT1) polymorphism rs16754 harbor adenine (A) or guanine (G). Recently, rs16754 has been reported to affect the outcome of patients with cytogenetically normal acute myeloid leukemia. To validate this finding, we investigated pretreatment features and outcome associated with rs16754 in a large cohort of patients with cytogenetically normal acute myeloid leukemia.
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