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Abstract
In most cases, neurological disorders that involve injuries of the cerebral white
matter are accompanied by demyelination and oligodendrocyte damage. Promotion of remyelination
process through the maturation of oligodendrocyte precursor cells (OPCs) is therefore
proposed to contribute to the development of novel therapeutic approaches that could
protect and restore the white matter from central nervous system diseases. However,
efficient remyelination in the white matter could not be accomplished if various neighboring
cell types are not involved to react with oligodendrocyte lineage cells in this process.
Hence, profound understanding of cell-cell interaction between oligodendrocyte lineage
cells and other cellular components is an essential step to achieve a breakthrough
for the cure of white matter injury. In this mini-review, we provide recent updates
on non-cell autonomous mechanisms of oligodendrocyte regeneration by introducing recent
studies (e.g. published either in 2018 or 2019) that focus on crosstalk between oligodendrocyte
lineage cells and the other constituents of the white matter.