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Interaction of methylmercury with microtubules in cultured cells and in vitro
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Abstract
The effects of methylmercury (MeHg) on cytoplasmic microtubules in cultured fibroblasts
and on the in vitro polymerization of microtubules were examined. MeHg caused disruption
of cellular microtubules in a concentration- and time-dependent manner. Addition of
the metal-chelating agent, dimercaptosuccinic acid (DMSA), both prevented and reversed
the effect of MeHg. Comparisons of the cellular levels of mercury and microtubule
integrity indicated that microtubules dissociated at levels higher than 0.6 microgram
Hg/mg protein. In vitro polymerization was also directly inhibited by MeHg; this effect
was prevented by the addition of DMSA.
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