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      The Efficacy and Safety of Deep Brain Stimulation of Combined Anterior Limb of Internal Capsule and Nucleus Accumbens (ALIC/NAcc-DBS) for Treatment-Refractory Obsessive-Compulsive Disorder: Protocol of a Multicenter, Randomized, and Double-Blinded Study.

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          Abstract

          Deep brain stimulation (DBS) is an emerging and promising therapeutic approach for treatment-refractory obsessive-compulsive disorder (OCD). The most common DBS targets include the anterior limb of internal capsule (ALIC) and nucleus accumbens (NAcc). This protocol aims to explore the efficacy and safety of the combined ALIC- and NAcc-DBS for treatment-refractory OCD.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Brain Sci
          Title: Brain sciences
          Publisher: MDPI AG
          ISSN: 2076-3425
          ISSN (Print): 2076-3425
          Publication date (Electronic): Jul 16 2022
          Volume: 12
          Issue: 7
          Affiliations
          [1 ] Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
          [2 ] West China Hospital, Sichuan University, Chengdu 610041, China.
          [3 ] The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450052, China.
          [4 ] Brains Hospital of Hunan Province, Changsha 410015, China.
          [5 ] First Affiliated Hospital of Kunming Medical University, Kunming 650031, China.
          [6 ] Huashan Hospital, Fudan University, Shanghai 200040, China.
          [7 ] Changhai Hospital, The Navy Military Medical University, Shanghai 200086, China.
          Article
          Publisher Item ID: brainsci12070933
          DOI: 10.3390/brainsci12070933
          PMC ID: 9313119
          PubMed ID: 35884739
          SO-VID: 4eed0805-806a-43e7-8364-4a2054bf7f66
          History

          Keywords: nucleus accumbens,obsessive-compulsive disorder,deep brain stimulation,anterior limb of internal capsule
          Data availability:
          Keywords: nucleus accumbens, obsessive-compulsive disorder, deep brain stimulation, anterior limb of internal capsule

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